| Literature DB >> 29909044 |
Abstract
Dengue virus (DENV) induces a proviral selective autophagy targeting lipid droplets, termed lipophagy, that stimulates lipid metabolism. Zhang et al. gained mechanistic insight into this process, demonstrating that DENV NS4A/B binds unmodified AUP1 and promotes its translocation from lipid droplets to autophagosomes to drive the induction of lipophagy.Entities:
Keywords: autophagy; lipid droplets; lipophagy; ubiquitin profiling
Mesh:
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Year: 2018 PMID: 29909044 DOI: 10.1016/j.tim.2018.05.010
Source DB: PubMed Journal: Trends Microbiol ISSN: 0966-842X Impact factor: 17.079