Literature DB >> 29907733

A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone.

Megan N Michalski1, Bart O Williams2.   

Abstract

Alterations in the SQSTM1 gene are a putative cause of Paget's disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the cell type believed to be the main pathological contributor. In this issue of JBC, Zach et al. provide important new evidence that the protein encoded by SQSTM1, p62, negatively regulates osteoclastogenesis and demonstrate that aged p62-deficient mice develop bone phenotypes similar to those of Paget's disease. These findings help to clarify the role of this important protein and present new opportunities to interrogate bone biology.
© 2018 Michalski and Williams.

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Year:  2018        PMID： 29907733      PMCID： PMC6005432          DOI： 10.1074/jbc.H118.003689

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.

Authors:  Anna Daroszewska; Robert J van 't Hof; Javier A Rojas; Robert Layfield; Euphemie Landao-Basonga; Lorraine Rose; Ken Rose; Stuart H Ralston
Journal:  Hum Mol Genet       Date:  2011-04-21       Impact factor: 6.150

2.  A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.

Authors:  Sarah L Rea; John P Walsh; Lynley Ward; Kirk Yip; Bryan K Ward; G Neil Kent; James H Steer; Jiake Xu; Thomas Ratajczak
Journal:  J Bone Miner Res       Date:  2006-07       Impact factor: 6.741

3.  p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone.

Authors:  Kirk H M Yip; Haotian Feng; Nathan J Pavlos; Ming H Zheng; Jiake Xu
Journal:  Am J Pathol       Date:  2006-08       Impact factor: 4.307

4.  Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.

Authors:  Noriyoshi Kurihara; Yuko Hiruma; Hua Zhou; Mark A Subler; David W Dempster; Frederick R Singer; Sakamuri V Reddy; Helen E Gruber; Jolene J Windle; G David Roodman
Journal:  J Clin Invest       Date:  2006-12-21       Impact factor: 14.808

5.  p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.

Authors:  Kyung Hee Chang; Amitava Sengupta; Ramesh C Nayak; Angeles Duran; Sang Jun Lee; Ronald G Pratt; Ashley M Wellendorf; Sarah E Hill; Marcus Watkins; Daniel Gonzalez-Nieto; Bruce J Aronow; Daniel T Starczynowski; Roberto Civitelli; Maria T Diaz-Meco; Jorge Moscat; Jose A Cancelas
Journal:  Cell Rep       Date:  2014-12-18       Impact factor: 9.423

6.  p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice.

Authors:  Frank Zach; Franziska Polzer; Alexandra Mueller; André Gessner
Journal:  J Biol Chem       Date:  2018-03-19       Impact factor: 5.157

7.  A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment.

Authors:  Yuko Hiruma; Noriyoshi Kurihara; Mark A Subler; Hua Zhou; Christina S Boykin; Heju Zhang; Seiichi Ishizuka; David W Dempster; G David Roodman; Jolene J Windle
Journal:  Hum Mol Genet       Date:  2008-09-02       Impact factor: 6.150

8.  The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

Authors:  Angeles Durán; Manuel Serrano; Michael Leitges; Juana M Flores; Sylvain Picard; Jacques P Brown; Jorge Moscat; Maria T Diaz-Meco
Journal:  Dev Cell       Date:  2004-02       Impact factor: 12.270

Review 9.  Paget's disease of bone.

Authors:  A Tan; S H Ralston
Journal:  QJM       Date:  2014-04-21

Review 10.  Pathobiology of Paget's Disease of Bone.

Authors:  Deborah L Galson; G David Roodman
Journal:  J Bone Metab       Date:  2014-05-31
  10 in total

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