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Literature DB >> 29907610

Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt.

Thomas A Leonard^1,2.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2018 PMID： 29907610 PMCID： PMC6142218 DOI： 10.1073/pnas.1808882115

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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11 in total

1. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

Authors: A Brunet; A Bonni; M J Zigmond; M Z Lin; P Juo; L S Hu; M J Anderson; K C Arden; J Blenis; M E Greenberg
Journal: Cell Date: 1999-03-19 Impact factor: 41.582

2. Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.

Authors: Robert J Romanelli; Andrew P LeBeau; Clifton G Fulmer; Deborah A Lazzarino; Alan Hochberg; Teresa L Wood
Journal: J Biol Chem Date: 2007-06-01 Impact factor: 5.157

3. PI(3,4,5)P₃ Engagement Restricts Akt Activity to Cellular Membranes.

Authors: Michael Ebner; Iva Lučić; Thomas A Leonard; Ivan Yudushkin
Journal: Mol Cell Date: 2017-02-02 Impact factor: 17.970

4. How to explain the AKT phosphorylation of downstream targets in the wake of recent findings.

Authors: Anil K Agarwal
Journal: Proc Natl Acad Sci U S A Date: 2018-06-15 Impact factor: 11.205

5. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.

Authors: Maya T Kunkel; Qiang Ni; Roger Y Tsien; Jin Zhang; Alexandra C Newton
Journal: J Biol Chem Date: 2004-12-06 Impact factor: 5.157

6. A family with severe insulin resistance and diabetes due to a mutation in AKT2.

Authors: Stella George; Justin J Rochford; Christian Wolfrum; Sarah L Gray; Sven Schinner; Jenny C Wilson; Maria A Soos; Peter R Murgatroyd; Rachel M Williams; Carlo L Acerini; David B Dunger; David Barford; A Margot Umpleby; Nicholas J Wareham; Huw Alban Davies; Alan J Schafer; Markus Stoffel; Stephen O'Rahilly; Inês Barroso
Journal: Science Date: 2004-05-28 Impact factor: 47.728

7. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.

Authors: Anne Brunet; Fumihiko Kanai; Justine Stehn; Jian Xu; Dilara Sarbassova; John V Frangioni; Sorab N Dalal; James A DeCaprio; Michael E Greenberg; Michael B Yaffe
Journal: J Cell Biol Date: 2002-02-25 Impact factor: 10.539

8. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Authors: Laura Braccini; Elisa Ciraolo; Carlo C Campa; Alessia Perino; Dario L Longo; Gianpaolo Tibolla; Marco Pregnolato; Yanyan Cao; Beatrice Tassone; Federico Damilano; Muriel Laffargue; Enzo Calautti; Marco Falasca; Giuseppe D Norata; Jonathan M Backer; Emilio Hirsch
Journal: Nat Commun Date: 2015-06-23 Impact factor: 14.919

Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt.

1. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

2. Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.

3. PI(3,4,5)P₃ Engagement Restricts Akt Activity to Cellular Membranes.

4. How to explain the AKT phosphorylation of downstream targets in the wake of recent findings.

5. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.

6. A family with severe insulin resistance and diabetes due to a mutation in AKT2.

7. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.

8. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

9. Localization of mTORC2 activity inside cells.

10. Conformational sampling of membranes by Akt controls its activation and inactivation.

Review 1. PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.

Review 2. Lipid-dependent Akt-ivity: where, when, and how.

3. Structure of autoinhibited Akt1 reveals mechanism of PIP₃-mediated activation.