Literature DB >> 29907492

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.

Soichiro Nakahara1, Sarah Medland2, Jessica A Turner3, Vince D Calhoun4, Kelvin O Lim5, Bryon A Mueller6, Juan R Bustillo5, Daniel S O'Leary7, Jatin G Vaidya7, Sarah McEwen8, James Voyvodic9, Aysenil Belger10, Daniel H Mathalon11, Judith M Ford11, Guia Guffanti12, Fabio Macciardi13, Steven G Potkin13, Theo G M van Erp14.   

Abstract

This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9). Gene set analysis identified unique and shared genes across cognitive domains. These findings suggest involvement of common and unique mechanisms across cognitive domains and may contribute to the discovery of new therapeutic targets to treat cognitive deficits in schizophrenia.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  GWAS; MCCB; Neuropsychology; PRS; Schizophrenia

Mesh：

Year:  2018        PMID： 29907492      PMCID： PMC6252137          DOI： 10.1016/j.schres.2018.05.041

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  42 in total

1.  The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization.

Authors:  Robert S Kern; Keith H Nuechterlein; Michael F Green; Lyle E Baade; Wayne S Fenton; James M Gold; Richard S E Keefe; Raquelle Mesholam-Gately; Jim Mintz; Larry J Seidman; Ellen Stover; Stephen R Marder
Journal:  Am J Psychiatry       Date:  2008-01-02       Impact factor: 18.112

2.  Genome-wide association study of cognitive decline in schizophrenia.

Authors:  Ryota Hashimoto; Masashi Ikeda; Kazutaka Ohi; Yuka Yasuda; Hidenaga Yamamori; Motoyuki Fukumoto; Satomi Umeda-Yano; Dwight Dickinson; Branko Aleksic; Masao Iwase; Hiroaki Kazui; Norio Ozaki; Daniel R Weinberger; Nakao Iwata; Masatoshi Takeda
Journal:  Am J Psychiatry       Date:  2013-06       Impact factor: 18.112

3.  Genome-wide association study identifies five new schizophrenia loci.

Authors: 
Journal:  Nat Genet       Date:  2011-09-18       Impact factor: 38.330

4.  Confirmed rare copy number variants implicate novel genes in schizophrenia.

Authors:  Gloria W C Tam; Louie N van de Lagemaat; Richard Redon; Karen E Strathdee; Mike D R Croning; Mary P Malloy; Walter J Muir; Ben S Pickard; Ian J Deary; Douglas H R Blackwood; Nigel P Carter; Seth G N Grant
Journal:  Biochem Soc Trans       Date:  2010-04       Impact factor: 5.407

5.  Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.

Authors:  Olav B Smeland; Oleksandr Frei; Karolina Kauppi; W David Hill; Wen Li; Yunpeng Wang; Florian Krull; Francesco Bettella; Jon A Eriksen; Aree Witoelar; Gail Davies; Chun C Fan; Wesley K Thompson; Max Lam; Todd Lencz; Chi-Hua Chen; Torill Ueland; Erik G Jönsson; Srdjan Djurovic; Ian J Deary; Anders M Dale; Ole A Andreassen
Journal:  JAMA Psychiatry       Date:  2017-10-01       Impact factor: 21.596

6.  Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

Authors:  G Davies; N Armstrong; J C Bis; J Bressler; V Chouraki; S Giddaluru; E Hofer; C A Ibrahim-Verbaas; M Kirin; J Lahti; S J van der Lee; S Le Hellard; T Liu; R E Marioni; C Oldmeadow; I Postmus; A V Smith; J A Smith; A Thalamuthu; R Thomson; V Vitart; J Wang; L Yu; L Zgaga; W Zhao; R Boxall; S E Harris; W D Hill; D C Liewald; M Luciano; H Adams; D Ames; N Amin; P Amouyel; A A Assareh; R Au; J T Becker; A Beiser; C Berr; L Bertram; E Boerwinkle; B M Buckley; H Campbell; J Corley; P L De Jager; C Dufouil; J G Eriksson; T Espeseth; J D Faul; I Ford; R F Gottesman; M E Griswold; V Gudnason; T B Harris; G Heiss; A Hofman; E G Holliday; J Huffman; S L R Kardia; N Kochan; D S Knopman; J B Kwok; J-C Lambert; T Lee; G Li; S-C Li; M Loitfelder; O L Lopez; A J Lundervold; A Lundqvist; K A Mather; S S Mirza; L Nyberg; B A Oostra; A Palotie; G Papenberg; A Pattie; K Petrovic; O Polasek; B M Psaty; P Redmond; S Reppermund; J I Rotter; H Schmidt; M Schuur; P W Schofield; R J Scott; V M Steen; D J Stott; J C van Swieten; K D Taylor; J Trollor; S Trompet; A G Uitterlinden; G Weinstein; E Widen; B G Windham; J W Jukema; A F Wright; M J Wright; Q Yang; H Amieva; J R Attia; D A Bennett; H Brodaty; A J M de Craen; C Hayward; M A Ikram; U Lindenberger; L-G Nilsson; D J Porteous; K Räikkönen; I Reinvang; I Rudan; P S Sachdev; R Schmidt; P R Schofield; V Srikanth; J M Starr; S T Turner; D R Weir; J F Wilson; C van Duijn; L Launer; A L Fitzpatrick; S Seshadri; T H Mosley; I J Deary
Journal:  Mol Psychiatry       Date:  2015-02-03       Impact factor: 15.992

7.  A global reference for human genetic variation.

Authors:  Adam Auton; Lisa D Brooks; Richard M Durbin; Erik P Garrison; Hyun Min Kang; Jan O Korbel; Jonathan L Marchini; Shane McCarthy; Gil A McVean; Gonçalo R Abecasis
Journal:  Nature       Date:  2015-10-01       Impact factor: 49.962

8.  Schizophrenia is associated with an increase in cortical microRNA biogenesis.

Authors:  N J Beveridge; E Gardiner; A P Carroll; P A Tooney; M J Cairns
Journal:  Mol Psychiatry       Date:  2009-09-01       Impact factor: 15.992

9.  Biological insights from 108 schizophrenia-associated genetic loci.

Authors: 
Journal:  Nature       Date:  2014-07-22       Impact factor: 49.962

10.  Proteomic Profiling of Mouse Liver following Acute Toxoplasma gondii Infection.

Authors:  Jun-Jun He; Jun Ma; Hany M Elsheikha; Hui-Qun Song; Dong-Hui Zhou; Xing-Quan Zhu
Journal:  PLoS One       Date:  2016-03-22       Impact factor: 3.240
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  8 in total

1.  Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects.

Authors:  Kazutaka Ohi; Daisuke Nishizawa; Shunsuke Sugiyama; Kentaro Takai; Ayumi Kuramitsu; Junko Hasegawa; Midori Soda; Kiyoyuki Kitaichi; Ryota Hashimoto; Kazutaka Ikeda; Toshiki Shioiri
Journal:  Int J Neuropsychopharmacol       Date:  2021-07-23       Impact factor: 5.176

Review 2.  Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.

Authors:  Kazutaka Ohi; Chika Sumiyoshi; Haruo Fujino; Yuka Yasuda; Hidenaga Yamamori; Michiko Fujimoto; Tomoko Shiino; Tomiki Sumiyoshi; Ryota Hashimoto
Journal:  Int J Mol Sci       Date:  2018-11-30       Impact factor: 5.923

3.  Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-Analysis.

Authors:  Jasmina Mallet; Yann Le Strat; Caroline Dubertret; Philip Gorwood
Journal:  J Clin Med       Date:  2020-01-25       Impact factor: 4.241

4.  Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls.

Authors:  Magnus Johan Engen; Siv Hege Lyngstad; Torill Ueland; Carmen Elisabeth Simonsen; Anja Vaskinn; Olav Smeland; Francesco Bettella; Trine Vik Lagerberg; Srdjan Djurovic; Ole A Andreassen; Ingrid Melle
Journal:  Transl Psychiatry       Date:  2020-11-30       Impact factor: 6.222

5.  Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach.

Authors:  Kai Zhao; Yujia Shi; Hon-Cheong So
Journal:  Pharmaceutics       Date:  2022-01-20       Impact factor: 6.321

6.  Consensus on potential biomarkers developed for use in clinical tests for schizophrenia.

Authors:  Ping Lin; Junyu Sun; Xiaoyan Lou; Dan Li; Yun Shi; Zhenhua Li; Peijun Ma; Ping Li; Shuzi Chen; Weifeng Jin; Shuai Liu; Qing Chen; Qiong Gao; Lili Zhu; Jie Xu; Mengyuan Zhu; Mengxia Wang; Kangyi Liang; Ling Zhao; Huabin Xu; Ke Dong; Qingtian Li; Xunjia Cheng; Jinghong Chen; Xiaokui Guo
Journal:  Gen Psychiatr       Date:  2022-02-23

7.  Adolescent Verbal Memory as a Psychosis Endophenotype: A Genome-Wide Association Study in an Ancestrally Diverse Sample.

Authors:  Baihan Wang; Olga Giannakopoulou; Isabelle Austin-Zimmerman; Haritz Irizar; Jasmine Harju-Seppänen; Eirini Zartaloudi; Anjali Bhat; Andrew McQuillin; Karoline Kuchenbäcker; Elvira Bramon
Journal:  Genes (Basel)       Date:  2022-01-03       Impact factor: 4.141

8.  Associations between hemispheric asymmetry and schizophrenia-related risk genes in people with schizophrenia and people at a genetic high risk of schizophrenia.

Authors:  Yue Zhu; Shuai Wang; Xiaohong Gong; Elliot K Edmiston; Suyu Zhong; Chao Li; Pengfei Zhao; Shengnan Wei; Xiaowei Jiang; Yue Qin; Jujiao Kang; Yi Wang; Qikun Sun; Gaolang Gong; Fei Wang; Yanqing Tang
Journal:  Br J Psychiatry       Date:  2021-07       Impact factor: 9.319
  8 in total

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