Kristina Thorsteinsson1, Merete Storgaard2, Terese L Katzenstein3, Steen Ladelund4, Frederikke F Rönsholt5, Isik Somuncu Johansen6, Gitte Pedersen7, Anne Gaardsting8, Lars Nørregård Nielsen9, Jesper Bonde10, Anne-Mette Lebech5. 1. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark. Electronic address: Kristina.thorsteinsson@regionh.dk. 2. Department of Infectious Diseases, Skejby, Aarhus University Hospital, Denmark. 3. Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark; Institute of Clinical Medicine, University of Copenhagen, Denmark. 4. Clinical Research Center, Hvidovre, Copenhagen University Hospital, Denmark. 5. Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark. 6. Department of Infectious Diseases, Odense University Hospital, Denmark. 7. Department of Infectious Diseases, Aalborg University Hospital, Denmark. 8. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark. 9. Department of Infectious Diseases, Nordsjællands Hospital, Copenhagen University Hospital, Denmark. 10. Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark.
Abstract
BACKGROUND: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection. Logistic regression models were used to identify predictors of anal and oral HPV. RESULTS: A total of 214 of 334 WLWH had sufficient DNA for analysis at all three anatomical sites and were included in analyses. Cervical, oral, and anal high-risk (hr) HPV prevalence were 28.0%, 3.7% and 39.3%. Most frequent i) cervical, ii) oral and iii) anal hrHPV genotypes were i) hrHPV58 (8.4%), 52 (5.1%), 16 (5.1%) and 51 (5.1%); ii) 52 (1.4%) and iii) 51 (9.3%), 58 (8.9%), 16 (7.0%) and 18 (7.0%). Among present cervical, oral, and anal hrHPV genotypes, 6.7%, 12.5% and 17.9% were targeted by the 2-or 4-valent HPV vaccines, whereas 50.0%, 50.0% and 42.9% of hrHPV genotypes were covered by the 9-valent HPV vaccine. Anal HPV infection was predicted by cervical HPV infection (adjusted OR 4.47 (95%CI 2.25-8.89)). CONCLUSION: Cervical and anal HPV infection were highly prevalent in WLWH. Non-16/18 hrHPV genotypes were predominant at all anatomical sites. Almost half of all hrHPV infections at the three anatomical sites could have been prevented by childhood/adolescent vaccination with the 9-valent HPV vaccine.
BACKGROUND:Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection. Logistic regression models were used to identify predictors of anal and oral HPV. RESULTS: A total of 214 of 334 WLWH had sufficient DNA for analysis at all three anatomical sites and were included in analyses. Cervical, oral, and anal high-risk (hr) HPV prevalence were 28.0%, 3.7% and 39.3%. Most frequent i) cervical, ii) oral and iii) anal hrHPV genotypes were i) hrHPV58 (8.4%), 52 (5.1%), 16 (5.1%) and 51 (5.1%); ii) 52 (1.4%) and iii) 51 (9.3%), 58 (8.9%), 16 (7.0%) and 18 (7.0%). Among present cervical, oral, and anal hrHPV genotypes, 6.7%, 12.5% and 17.9% were targeted by the 2-or 4-valent HPV vaccines, whereas 50.0%, 50.0% and 42.9% of hrHPV genotypes were covered by the 9-valent HPV vaccine. Anal HPV infection was predicted by cervical HPV infection (adjusted OR 4.47 (95%CI 2.25-8.89)). CONCLUSION: Cervical and anal HPV infection were highly prevalent in WLWH. Non-16/18 hrHPV genotypes were predominant at all anatomical sites. Almost half of all hrHPV infections at the three anatomical sites could have been prevented by childhood/adolescent vaccination with the 9-valent HPV vaccine.
Keywords:
Cervical cancer, anal cancer; Concordance; Genotype distribution; HPV prevalence; HPV vaccine; Human papillomavirus; Oral cancer; Women living with HIV
Authors: Milagros Pérez-Quintanilla; Rocío Méndez-Martínez; Salvador Vázquez-Vega; Raquel Espinosa-Romero; Rita Sotelo-Regil; María Delia Pérez-Montiel; Ubaldo Ramos-Alamillo; Teresita de Jesús Cabrera-López; Salim Abraham Barquet-Muñoz; Carlos Pérez-Plascencia; Alejandro García-Carrancá; David Cantú de León Journal: PLoS One Date: 2020-04-22 Impact factor: 3.240