| Literature DB >> 29905905 |
F I Tade1, W G Wiles2, G Lu3, B Bilir4, O Akin-Akintayo1, J S Lee1, D Patil2, W Yu1, C Ormenisan Gherasim4, B Fei1, C S Moreno4, A O Osunkoya2,4,5, E J Teoh6, S Oka7, H Okudaira7, M M Goodman1, D M Schuster8.
Abstract
We investigated if previously demonstrated inhibition of fluciclovine (18F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls (n = 2). Partial inhibition of fluciclovine uptake by BCH and MeAIB can be demonstrated in vivo similar to previous in vitro modeling.Entities:
Keywords: Amino acid transport; Axumin; Fluciclovine; PC3; Prostate cancer
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Year: 2018 PMID： 29905905 PMCID： PMC7261602 DOI： 10.1007/s00726-018-2600-0
Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520