Reginald Lee1, Lauren Singh1, Danielle van Liefde1, Meghan Callaghan-Gillespie1, Matilda Steiner-Asiedu2, Kwesi Saalia2, Carly Edwards3, Anja Serena4, Tamara Hershey5,6,7, Mark J Manary1,8,9. 1. Departments of Pediatrics, Washington University, St. Louis, MO. 2. Department of Nutrition and Food Science, University of Ghana, Legon, Ghana. 3. Project Peanut Butter, Kumasi, Ghana. 4. Global Nutrition and Clinicals, Arla Foods Amba, Brabrand, Denmark. 5. Departments of Psychiatry, Washington University, St. Louis, MO. 6. Departments of Neurology, Washington University, St. Louis, MO. 7. Departments of Radiology, Washington University, St. Louis, MO. 8. School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi. 9. Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX.
Abstract
Background: The inclusion of milk in school feeding is accepted as good nutritional practice, but specific benefits remain uncertain. Objective: The objective was to determine whether consumption of 8.8 g milk protein/d given as milk powder with a multiple micronutrient-enriched porridge resulted in greater increases in linear growth and Cambridge Neuropsychological Test Automated Battery (CANTAB) scores in Ghanaian schoolchildren when compared with 1 of 3 control groups. Methods: A randomized, double-blind, placebo-controlled clinical trial in healthy children aged 6-9 y was conducted comparing 8.8 g milk protein/d with 4.4 g milk protein/d or 4.4 g milk protein + 4.4 g rice protein/d (isonitrogenous, half of the protein from milk and half from rice) or a non-nitrogenous placebo. Primary outcomes were changes in length after 9 mo and CANTAB scores after 4.5 mo; secondary outcomes were body-composition measures. Supplements were added to porridge each school day and consumed for 9 mo. Anthropometric and body-composition measures and CANTAB tests were completed upon enrollment and after 4.5 and 9 mo. Group results were compared by using ANCOVA for anthropometric measures and the Kruskal-Wallis test for CANTAB scores. Results: Children receiving 8.8 g milk protein/d showed greater increases on percentage correct in Pattern Recognition Memory (mean ± SD: 5.5% ± 16.8%; P < 0.05) and Intra/Extradimensional Set Shift completed stages compared with all other food groups (0.6 ± 2.3; P < 0.05). No differences were seen in linear growth between the groups. The children receiving either 4.4 or 8.8 g milk protein/d had a higher fat-free body mass index than those who received no milk, with an effect size of 0.34 kg/m2. Conclusion: Among schoolchildren, the consumption of 8.8 g milk protein/d improved executive cognitive function compared with other supplements and led to the accretion of more lean body mass, but not more linear growth. This trial was registered at www.clinicaltrials.gov">www.clinicaltrials.gov as NCT02757508.
RCT Entities:
Background: The inclusion of milk in school feeding is accepted as good nutritional practice, but specific benefits remain uncertain. Objective: The objective was to determine whether consumption of 8.8 g milk protein/d given as milk powder with a multiple micronutrient-enriched porridge resulted in greater increases in linear growth and Cambridge Neuropsychological Test Automated Battery (CANTAB) scores in Ghanaian schoolchildren when compared with 1 of 3 control groups. Methods: A randomized, double-blind, placebo-controlled clinical trial in healthy children aged 6-9 y was conducted comparing 8.8 g milk protein/d with 4.4 g milk protein/d or 4.4 g milk protein + 4.4 g rice protein/d (isonitrogenous, half of the protein from milk and half from rice) or a non-nitrogenous placebo. Primary outcomes were changes in length after 9 mo and CANTAB scores after 4.5 mo; secondary outcomes were body-composition measures. Supplements were added to porridge each school day and consumed for 9 mo. Anthropometric and body-composition measures and CANTAB tests were completed upon enrollment and after 4.5 and 9 mo. Group results were compared by using ANCOVA for anthropometric measures and the Kruskal-Wallis test for CANTAB scores. Results:Children receiving 8.8 g milk protein/d showed greater increases on percentage correct in Pattern Recognition Memory (mean ± SD: 5.5% ± 16.8%; P < 0.05) and Intra/Extradimensional Set Shift completed stages compared with all other food groups (0.6 ± 2.3; P < 0.05). No differences were seen in linear growth between the groups. The children receiving either 4.4 or 8.8 g milk protein/d had a higher fat-free body mass index than those who received no milk, with an effect size of 0.34 kg/m2. Conclusion: Among schoolchildren, the consumption of 8.8 g milk protein/d improved executive cognitive function compared with other supplements and led to the accretion of more lean body mass, but not more linear growth. This trial was registered at www.clinicaltrials.gov">www.clinicaltrials.gov as NCT02757508.
Authors: Yankho Kaimila; Oscar Divala; Sophia E Agapova; Kevin B Stephenson; Chrissie Thakwalakwa; Indi Trehan; Mark J Manary; Kenneth M Maleta Journal: Nutrients Date: 2019-02-25 Impact factor: 5.717
Authors: Mette F Olsen; Ann-Sophie Iuel-Brockdorff; Charles W Yaméogo; Bernardette Cichon; Christian Fabiansen; Suzanne Filteau; Kevin Phelan; Albertine Ouédraogo; Kim F Michaelsen; Melissa Gladstone; Per Ashorn; André Briend; Christian Ritz; Henrik Friis; Vibeke B Christensen Journal: PLoS Med Date: 2020-12-23 Impact factor: 11.069