Literature DB >> 29904918

T cell development and the physiological role of O-GlcNAc.

Lara K Abramowitz1, John A Hanover1.   

Abstract

O-GlcNAcylation is an essential post-translational modification important for integrating metabolism with cell physiology. Using diverse model systems, studies of this evolutionarily conserved intracellular glycosylation have highlighted its role in stem cell maintenance, lineage specification, and disease. Although discovered over 30 years ago, the study of O-GlcNAc continues to evolve and uncover surprising roles for O-GlcNAc and the enzymes of O-GlcNAc cycling: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). In this review, using the immune system as a model of stem cell biology and cell fate determination, we discuss how O-GlcNAc is at the nexus of metabolism, proliferation, and disease. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

Entities:  

Keywords:  O-GlcNAc; O-GlcNAc transferase; O-GlcNAcase; T cell development; cancer; glycosylation; hematopoiesis; post-translational modifications; proliferation; stem cells

Mesh：

Substances：

Year:  2018        PMID： 29904918     DOI： 10.1002/1873-3468.13159

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

Review 1.  Prohibitin: a prime candidate for a pleiotropic effector that mediates sex differences in obesity, insulin resistance, and metabolic dysregulation.

Authors:  Yang Xin Zi Xu; Geetika Bassi; Suresh Mishra
Journal:  Biol Sex Differ       Date:  2019-05-22       Impact factor: 5.027

2.  New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth.

Authors:  Matjaž Weiss; Elena M Loi; Maša Sterle; Cyril Balsollier; Tihomir Tomašič; Roland J Pieters; Martina Gobec; Marko Anderluh
Journal:  Front Chem       Date:  2021-04-14       Impact factor: 5.221

3.  Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia.

Authors:  Tiago Oliveira; Mingfeng Zhang; Eun Ji Joo; Hisham Abdel-Azim; Chun-Wei Chen; Lu Yang; Chih-Hsing Chou; Xi Qin; Jianjun Chen; Kathirvel Alagesan; Andreia Almeida; Francis Jacob; Nicolle H Packer; Mark von Itzstein; Nora Heisterkamp; Daniel Kolarich
Journal:  Theranostics       Date:  2021-09-21       Impact factor: 11.600

Review 4.  Protein O-GlcNAcylation Regulates Innate Immune Cell Function.

Authors:  Hong Dong; Zihao Liu; Haitao Wen
Journal:  Front Immunol       Date:  2022-02-03       Impact factor: 8.786

Review 5.  The Beginner's Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System.

Authors:  Michael P Mannino; Gerald W Hart
Journal:  Front Immunol       Date:  2022-01-31       Impact factor: 7.561

Review 6.  Metabolic regulation of T cell development.

Authors:  Mengdi Zhang; Xiaoxi Lin; Zhou Yang; Xia Li; Zhiguang Zhou; Paul E Love; Jiaqi Huang; Bin Zhao
Journal:  Front Immunol       Date:  2022-07-25       Impact factor: 8.786

7.  O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity.

Authors:  Eunah Kim; Jeong Gu Kang; Min Jueng Kang; Jae Hyung Park; Yeon Jung Kim; Tae Hyun Kweon; Han-Woong Lee; Eek-Hoon Jho; Yong-Ho Lee; Seung-Il Kim; Eugene C Yi; Hyun Woo Park; Won Ho Yang; Jin Won Cho
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-08       Impact factor: 11.205

8.  Inhibition of O-GlcNAc Transferase Alters the Differentiation and Maturation Process of Human Monocyte Derived Dendritic Cells.

Authors:  Matjaž Weiss; Marko Anderluh; Martina Gobec
Journal:  Cells       Date:  2021-11-26       Impact factor: 6.600
  8 in total

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