Literature DB >> 2990487

Inhibition of phosphatidylinositol phosphodiesterase activity in skeletal muscle by metal ions and drugs which block neuromuscular transmission.

J K Shute, M E Smith.   

Abstract

The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and the quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.

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Year:  1985        PMID： 2990487     DOI： 10.1016/0006-2952(85)90528-3

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  4 in total

1.  Lupeol inhibits migration and invasion of colorectal cancer cells by suppressing RhoA-ROCK1 signaling pathway.

Authors:  Yiwen Jiang; Dan Hong; Zhefeng Lou; Xuezi Tu; Longjin Jin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2020-02-06       Impact factor: 3.000

2.  Effect of soluble factors from nerve and muscle on alpha-bungarotoxin binding sites in isolated sarcolemmal membranes of the rat.

Authors:  A J Harborne; M E Smith
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

3.  The influx of Ca2+ induced by the administration of glucagon and Ca2+-mobilizing agents to the perfused rat liver could involve at least two separate pathways.

Authors:  J G Altin; F L Bygrave
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857

4.  Neurotoxic aminoglycoside antibiotics are potent inhibitors of [125I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes.

Authors:  H G Knaus; J Striessnig; A Koza; H Glossmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000
  4 in total

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