Literature DB >> 2990473

Activation of human platelets by ADP causes a rapid rise in cytosolic free calcium without hydrolysis of phosphatidylinositol-4,5-bisphosphate.

G J Fisher, S Bakshian, J J Baldassare.   

Abstract

Phosphatidylinositol-4,5-bisphosphate decreased 40% within 10 seconds after the addition of thrombin to platelets. This thrombin-induced loss was accompanied by a corresponding increase of inositol phosphates. In contrast, within the first 60 seconds after exposure of platelets to ADP there was no detectable change in the amounts of phosphatidylinositol-4,5-bisphosphate or inositol phosphates. Both thrombin and ADP, however, caused a very rapid rise of cytosolic free calcium, as measured by Quin-2. The magnitude of this rise of calcium was similar for the two agonists. These results suggest that in platelets, agonist stimulation may lead to increased cytosolic free calcium independently of phosphatidylinositol-4,5-bisphosphate degradation.

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Year:  1985        PMID： 2990473     DOI： 10.1016/0006-291x(85)91984-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  21 in total

1.  Particulate guanylate cyclase and adenylate cyclase activities after activation with various agents in rabbit platelets. An ultracytochemical study.

Authors:  A Spreca; M G Rambotti; R Donato
Journal:  Histochem J       Date:  1991-03

2.  Spiking in cytosolic calcium concentration in single fibrinogen-bound fura-2-loaded human platelets.

Authors:  J W Heemskerk; J Hoyland; W T Mason; S O Sage
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

3.  Agonist-evoked changes in cytosolic pH and calcium concentration in human platelets: studies in physiological bicarbonate.

Authors:  S O Sage; T M Jobson; T J Rink
Journal:  J Physiol       Date:  1990-01       Impact factor: 5.182

4.  Calpain I remains intact and intracellular during platelet activation. Immunochemical measurements with monoclonal and polyclonal antibodies.

Authors:  J A Samis; G Zboril; J S Elce
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

5.  Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets.

Authors:  K A Williams; W Murphy; R J Haslam
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

6.  Calcium efflux from platelet vesicles of the dense tubular system. Analysis of the possible contribution of the Ca2+ pump.

Authors:  R G Teijeiro; J R Sotelo Silveira; J R Sotelo; J C Benech
Journal:  Mol Cell Biochem       Date:  1999-09       Impact factor: 3.396

7.  Phosphorylation-dependent and -independent pathways of platelet aggregation.

Authors:  S P Watson; S Hambleton
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

8.  Thrombin-induced inositol trisphosphate production by rabbit platelets is inhibited by ethanol.

Authors:  M L Rand; J D Vickers; R L Kinlough-Rathbone; M A Packham; J F Mustard
Journal:  Biochem J       Date:  1988-04-01       Impact factor: 3.857

Review 9.  Harnessing the platelet signaling network to produce an optimal hemostatic response.

Authors:  Lawrence F Brass; Maurizio Tomaiuolo; Timothy J Stalker
Journal:  Hematol Oncol Clin North Am       Date:  2013-04-11       Impact factor: 3.722

10.  Sub-second oscillations of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate during platelet activation by ADP and thrombin: lack of correlation with calcium kinetics.

Authors:  S Raha; G D Jones; A R Gear
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857
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