Literature DB >> 2990462

Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin.

P M Lad, C V Olson, I S Grewal.   

Abstract

Pretreatment of human neutrophils with pertussis toxin inhibits platelet-activating factor-mediated chemotaxis, superoxide generation, aggregation, and release of lysozyme. By contrast, superoxide generation observed in the presence of phorbol-12-myristate-13 acetate is unaffected. Our results suggest that a target protein for pertussis toxin, probably a GTP binding protein termed "Ni", is involved in the actions of platelet-activating factor on human neutrophils.

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Year:  1985        PMID： 2990462     DOI： 10.1016/0006-291x(85)91938-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response.

Authors:  Giovanna Leoni; Jeannie Gripentrog; Connie Lord; Marcia Riesselman; Ronen Sumagin; Charles A Parkos; Asma Nusrat; Algirdas J Jesaitis
Journal:  J Leukoc Biol       Date:  2014-11-13       Impact factor: 4.962

2.  Priming effects of leukotriene B4 on endothelial cell injury induced by TPA-activated leukocytes.

Authors:  N Suda; I Morita; T Kuroda; S Murota
Journal:  Inflammation       Date:  1992-08       Impact factor: 4.092

Review 3.  Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor.

Authors:  A G Rossi; J T O'Flaherty
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

Review 4.  Inositol phospholipid turnover in PAF transmembrane signalling.

Authors:  S D Shukla
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

5.  Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502.

Authors:  R A Hilger; M Köller; W König
Journal:  Inflammation       Date:  1996-02       Impact factor: 4.092

6.  Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs.

Authors:  C D Arreto; M F Bureau; A Imaizumi; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

7.  Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

Authors:  J A Nick; N J Avdi; S K Young; C Knall; P Gerwins; G L Johnson; G S Worthen
Journal:  J Clin Invest       Date:  1997-03-01       Impact factor: 14.808

8.  Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils.

Authors:  P P McDonald; S R McColl; P Braquet; P Borgeat
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

9.  Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells.

Authors:  S G Ward; J Westwick
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

10.  Studies on the activation of human neutrophil 5-lipoxygenase induced by natural agonists and Ca2+ ionophore A23187.

Authors:  P P McDonald; S R McColl; P H Naccache; P Borgeat
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857
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