Literature DB >> 2990455

Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.

S M Chung, A D Proia, G K Klintworth, S P Watson, E G Lapetina.   

Abstract

Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2990455     DOI： 10.1016/0006-291x(85)90166-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  The formation of lysophosphatidylinositol phosphate in human platelet microsomes.

Authors:  L M Thomas; B J Holub
Journal:  Lipids       Date:  1987-03       Impact factor: 1.880

2.  Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes.

Authors:  E Claro; A Garcia; F Picatoste
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857

3.  Guanine nucleotide- and muscarinic agonist-dependent phosphoinositide metabolism in synaptoneurosomes from cerebral cortex of immature rats.

Authors:  S M Candura; A F Castoldi; L Manzo; L G Costa
Journal:  Neurochem Res       Date:  1992-11       Impact factor: 3.996
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.