Literature DB >> 29904420

Analysis of the efficacy of resveratrol treatment in patients with scarred uterus.

Huashu Ma1, Zongxu Qiao1.   

Abstract

Scarred uterus is caused by cesarean section surgery, and this condition affects further gestation and delivery in patients. Previous evidence suggested that resveratrol, a polyphenol compound, presents beneficial outcomes for patients with scarred uterus. Therefore, the aim of the present study was to analyze the efficacy of resveratrol in the treatment of patients with scarred uterus. The efficacy of resveratrol in the formation of new vessels and re-epithelialization of the endometrium was analyzed. The present results demonstrated that resveratrol treatment reduced uterus scarring in the majority of patients (87.36%) compared with the control. It was also observed that the plasma levels of β-human chorionic gonadotropin were downregulated by resveratrol treatment in patients with scarred uterus. Furthermore, resveratrol treatment promoted the remodeling of the scarred uterus, the regeneration of the endometrium and improved pregnancy outcomes. In conclusion, the findings of the current study indicate that resveratrol treatment may be a potential strategy for the treatment of scarred uterus patients, which contributes to the improvement of pregnancy outcomes.

Entities:  

Keywords:  endometrium; pregnancy; resveratrol; scarred uterus

Year:  2018        PMID: 29904420      PMCID: PMC5996716          DOI: 10.3892/etm.2018.6126

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN: 1792-0981            Impact factor:   2.447


  25 in total

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Authors:  Haifeng Zhao; Qiao Niu; Xuemin Li; Tiantian Liu; Yunan Xu; Hao Han; Wanrong Wang; Ningxiu Fan; Qinqin Tian; Huifeng Zhang; Zelan Wang
Journal:  Brain Res       Date:  2012-05-27       Impact factor: 3.252

2.  Successful pregnancy after spontaneous rupture of scarred uterus following fundal myomectomy.

Authors:  S Skrablin; V Banovic; I Kuvacic
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2005-08-01       Impact factor: 2.435

3.  An unusual case of tear in the pouch of Douglas following spontaneous vaginal delivery in a previously scarred uterus.

Authors:  N Shantha; J Depares
Journal:  J Obstet Gynaecol       Date:  2007-01       Impact factor: 1.246

4.  Long-term resveratrol treatment prevents ovariectomy-induced osteopenia in rats without hyperplastic effects on the uterus.

Authors:  Haifeng Zhao; Xuemin Li; Na Li; Tiantian Liu; Juan Liu; Ziwei Li; Huihui Xiao; Jinhui Li
Journal:  Br J Nutr       Date:  2013-09-30       Impact factor: 3.718

5.  Intravaginal gemeprost and second-trimester pregnancy termination in the scarred uterus.

Authors:  E Marinoni; M Santoro; M P Vitagliano; A Patella; E V Cosmi; R Di Iorio
Journal:  Int J Gynaecol Obstet       Date:  2007-02-22       Impact factor: 3.561

6.  Assessment of ischemia-induced microvascular remodeling using contrast-enhanced ultrasound vascular anatomic mapping.

Authors:  Marco Pascotto; Howard Leong-Poi; Beat Kaufmann; Achim Allrogen; Dimitrios Charalampidis; Edmund K Kerut; Sanjiv Kaul; Jonathan R Lindner
Journal:  J Am Soc Echocardiogr       Date:  2007-06-12       Impact factor: 5.251

7.  Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease.

Authors:  Jürgen Knobloch; Chiara Wahl; Maria Feldmann; David Jungck; Justus Strauch; Erich Stoelben; Andrea Koch
Journal:  Basic Clin Pharmacol Toxicol       Date:  2013-09-30       Impact factor: 4.080

8.  Resveratrol inhibits the deleterious effects of diet-induced obesity on thymic function.

Authors:  Apeksha A Gulvady; Henry P Ciolino; Robert M Cabrera; Christopher A Jolly
Journal:  J Nutr Biochem       Date:  2013-04-03       Impact factor: 6.048

9.  Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism.

Authors:  Albino Carrizzo; Annibale Puca; Antonio Damato; Marina Marino; Elio Franco; Franco Pompeo; Anna Traficante; Fabio Civitillo; Luigi Santini; Valentina Trimarco; Carmine Vecchione
Journal:  Hypertension       Date:  2013-06-10       Impact factor: 10.190

10.  Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle.

Authors:  Ha T Tran; Stella Liong; Ratana Lim; Gillian Barker; Martha Lappas
Journal:  PLoS One       Date:  2017-03-09       Impact factor: 3.240

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  1 in total

1.  Localized Therapy of Vaginal Infections and Inflammation: Liposomes-In-Hydrogel Delivery System for Polyphenols.

Authors:  May Wenche Jøraholmen; Purusotam Basnet; Mia Jonine Tostrup; Sabrin Moueffaq; Nataša Škalko-Basnet
Journal:  Pharmaceutics       Date:  2019-01-27       Impact factor: 6.321

  1 in total

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