Literature DB >> 29904222

Health-system-adapted data envelopment analysis for decision-making in universal health coverage.

Mark G Shrime1, Swagoto Mukhopadhyay2, Blake C Alkire1.   

Abstract

OBJECTIVE: To develop and test a method that allows an objective assessment of the value of any health policy in multiple domains.
METHODS: We developed a method to assist decision-makers with constrained resources and insufficient knowledge about a society's preferences to choose between policies with unequal, and at times opposing, effects on multiple outcomes. Our method extends standard data envelopment analysis to address the realities of health policy, such as multiple and adverse outcomes and a lack of information about the population's preferences over those outcomes. We made four modifications to the standard analysis: (i) treating the policy itself as the object of analysis, (ii) allowing the method to produce a rank-ordering of policies; (iii) allowing any outcome to serve as both an output and input; and (iv) allowing variable return to scale. We tested the method against three previously published analyses of health policies in low-income settings.
RESULTS: When applied to previous analyses, our new method performed better than traditional cost-effectiveness analysis and standard data envelopment analysis. The adapted analysis could identify the most efficient policy interventions from among any set of evaluated policies and was able to provide a rank ordering of all interventions.
CONCLUSION: Health-system-adapted data envelopment analysis allows any quantifiable attribute or determinant of health to be included in a calculation. It is easy to perform and, in the absence of evidence about a society's preferences among multiple policy outcomes, can provide a comprehensive method for health-policy decision-making in the era of sustainable development.

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Year:  2018        PMID: 29904222      PMCID: PMC5996217          DOI: 10.2471/BLT.17.191817

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN: 0042-9686            Impact factor:   9.408


Introduction

In 2015, the United Nations adopted 17 sustainable development goals, reflecting a commitment to end poverty in all forms by 2030. Among the targets of the third goal is the establishment of universal health coverage (UHC), ensuring “all people and communities can use the promotive, preventive, curative, rehabilitative and palliative health services they need, of sufficient quality to be effective, while also ensuring that the use of these services does not expose the user to financial hardship”. Achieving this requires countries to expand the number of health conditions covered, improve the quality of services, increase the number of people covered and provide protection against financial risk. Health policy decision-making is complicated, however, by the fact that no health policy can improve coverage, equity, quality and financial risk protection simultaneously and to the same degree. This forces policy-makers to confront challenging resource-allocation questions: Is it more important for society to cover more people, treat more conditions, improve equity or increase financial protection? Ideally, choosing among different policies (Box 1) requires knowledge about the population’s preferences, knowledge which may not exist.

Policy A

Policy characteristics: Cost US$ 175 000 200 deaths averted 40 cases of catastrophic health expenditure created Mildly favours richer patients This policy improves health the most, but is mildly regressive and creates catastrophic medical expenditure for patients

Policy B

Policy characteristics: Cost US$ 150 000 40 deaths averted 20 cases of catastrophic health expenditure averted Mildly favours poorer patients This policy is less regressive than Policy A and provides financial risk protection, (i.e. negative cases of catastrophic expenditure created) but delivers the least health benefit.

Policy C

Policy characteristics: Cost US$ 200 000 80 deaths averted 60 cases of catastrophic health expenditure created Strongly favours poorer patients This policy is the most equitable of the three and provides a moderate amount of health improvement, but creates the most financial catastrophe and is the most expensive.

Choosing among these policies

Ideally, choosing among the three would require knowledge about the target population’s preference weights across health, financial risk protection, equity and cost. In the absence of such knowledge, balancing the competing outcomes is difficult, and is the subject of the method presented here. US$: United States dollars. Analytical models such as extended cost‒effectiveness analyses can make the health, financial and equity effects of policies explicit.– The newest recommendations of the Second Panel on Cost–Effectiveness in Health and Medicine advocate including an impact inventory of the non-health outcomes of medical interventions, such as economic productivity., However, other than simply reporting multiple outcomes, no method exists for decision-making that balances these many, and sometimes conflicting, domains. This paper describes the development of a method for health policy decision-making in the absence of knowledge about a society’s preferences, with modifications for dealing with undesired outcomes. The method is an extension of standard data envelopment analysis, adapted for health policymaking; it combines the costs of health policies with their effects on multiple disparate domains into a single rank-ordering. We evaluated the method by applying it to the findings of three previous extended cost–effectiveness analyses.

Methods

Measuring value in health

The literature of cost–effectiveness research, and, more recently, of value-based health care has defined value as:Although theoretically attractive, operationalizing this ratio is difficult when there are multiple inputs and outputs. To illustrate the concept of preference weighting we can consider two health-care policies: (i) training community health workers, which costs United States dollars (US$) 10 000, requires 10 faculty, averts 500 disability-adjusted life-years, and prevents 10 instances of catastrophic expenditure annually; or (ii) training specialists, which costs US$ 100 000, requires 20 faculty, and averts 600 disability-adjusted life-years and 12 instances of catastrophic expenditure annually. Cost‒effectiveness analysis looks only at costs and health benefits. The first policy costs US$ 20 per disability-adjusted life-years averted, while the second policy carries an incremental cost‒effectiveness ratio of US$ 900 disability-adjusted life-years averted. Decision-making is straightforward: if these ratios are less than society’s willingness to pay, the policy is deemed cost–effective. This betrays an underlying assumption, not consistent with reality: that health effects and costs are sufficient metrics for decision-making. Patients, for example, may choose health care based on other factors such as affordability, satisfaction, distance or time. How people judge these trade-offs (that is, their underlying preference structure) is unknown. Furthermore, this preference structure is likely to vary across patients, be difficult to assess and not predicted by patients’ demographics. Patient-centred policy, then, must account for the fact that health effects and costs are valued against other inputs and outcomes. At the same time, laborious assessments of preference structures for every policy decision are impossible. Equation (1) can be extended to encompass more fully the examples above, including the domains of personnel and financial catastrophe, in addition to health and cost:The preference weight coefficients (u and v) formalize the trade-offs inherent in decision-making; that is, how important health and costs are relative to other outputs and inputs (cost‒effectiveness assumes u2 and v2 are zero). Instead of attempting to determine the population’s values for u and v, our proposed method sets the preference weights as unknown and solves for them instead. To do so, it must impose two constraints: (i) the value of any policy must remain between 0 and 1 (inclusive); and (ii) u and v must take some positive value. With these constraints in place, the analysis finds solutions for u and v such that the value of each policy is as high as possible, while the values for all other potential policies, using these same preference weights, meet the constraints set above. This allows each policy to be judged on its own merits.

Data envelopment analysis

To calculate value of a policy without specifying the relative importance of inputs and outputs, the analysis instead allows each policy to set its own preference weights. Mathematically, we start with the first policy, p, out of a set of K total policies. p will use some amount of input (x) and produce some amount of output (y). The value of p, which we call θ, is a generalization of Equation (2): Importantly, inputs and outputs are treated as having no units of measurement. That is, inputs could include square feet of hospital space, numbers of nurses and costs of the policy, while outputs could include deaths averted, impacts on a country’s gross domestic product and measures of equity. The constraints imposed above make this a linear optimization problem in which θ is maximized such that all efficiencies for all K policies are at most 1, and no policy is allowed to put zero weight on any input or output:A value of 1 suggests that no other policy is producing more outputs for a given set of inputs than p0. A value < 1 implies that po could do better (that is, other policies would convert its inputs into more outputs more efficiently). Note that because the efficiency for each policy is calculated using the optimization, the relative importance weights, u and v, are recalculated for each policy. As a result, any inefficient policy can no longer be blamed on some external imposition of weights. Unfortunately, because each policy sets its own weights, it is conceivable, and in fact likely, for many to appear efficient, leaving the policy-maker with little guidance.

Modifications for health policy

Four additional modifications are necessary to adapt data envelopment analysis to health policy applications. The first modification, already done above, is to treat the policy itself as the object of analysis, as opposed to any policy-maker, hospital or provider. This can be done because policies have direct consequences on the population’s health, financial well-being and equity (that is, they have direct outputs). Doing so requires decisions about cost, workforce training, infrastructure development and other inputs. The second modification addresses the problem posed by multiple efficient policies. In real-world applications of Equation (4), many policies end up having a value of 1 (the maximum), which does not help the policy-maker. To produce a rank-ordering of policies, the first constraint in Equation (4) must be relaxed: in this so-called superefficiency analysis θ is allowed to be larger than 1, while values for every other policy remain constrained.θ is calculated for the first policy, subject to the constraint that the value of all other policies remain between 0 and 1. This θ is recorded, and the cycle repeats itself for the second policy. When θ is calculated it is allowed to be larger than 1, but in that calculation, θ is constrained. Once this calculation is done, θ is recorded, and Equation (5) is repeated for the third decision-making unit, and so on. This relaxation of constraints begins to produce rank orderings of health policies. However, a third modification is required. Equations (4) and (5) assume a constant return to scale, that is, that each additional unit of inputs (e.g. costs, personnel), will produce exactly the same unit of outputs as the one before. This is unlikely to be true in health. Policies that put a single surgeon in a previously unstaffed hospital, for example, are likely to return a significantly larger health benefit than those adding a second surgeon to a hospital that already has one. Allowing variable return to scale requires some added calculation, which has been developed elsewhere. Infeasibility is contravened by the Cook modification. One final modification is necessary to apply data envelopment analysis to health policy. In manufacturing, from which the method is derived, a producer cannot produce negative numbers of a product. In rare cases of negative outputs, the standard practice is to scale manufacturers’ outputs such that negative production no longer happens. That is, if a factory produces, 20 units of a product, 20 units of that product are simply added to the output of all factories, such that the negatively-producing manufacturer now produces 0, and every other manufacturer produces 20 more than previously. Although this may be mathematically justified, the translation to health is tenuous. For example, some policies can improve health, but worsen catastrophic out-of-pocket expenses for patients, thereby producing negative financial risk protection. Linear scaling would imply that such policies no longer produce any impoverishment, but that all other policies arbitrarily now provide even more protection against impoverishment. The probability that patients would find these two scenarios equivalent is low, making such scaling unhelpful to a decision-maker. A health-policy-adapted framework must take this into account. We therefore allowed any outcome to serve as both an output and an input. For example, in cases of negative financial risk protection (that is, increased catastrophic expense) the additional financial risk produced by a policy is counted as a cost (or input) to the analysis. When catastrophic expense is prevented, the financial risk protection is counted as an output of the analysis. This modification penalizes policies with negative outcomes by increasing the size of the denominator in Equation (1), thereby decreasing that policy’s efficiency.

Data sources and analysis

We tested our health-adapted superefficiency data envelopment analysis method by applying it to data from three previously published extended cost‒effectiveness analyses of policy inteventions.,, The first example was an analysis of policies to increase access to surgery in Ethiopia in terms of the cost, health benefits and effects on financial risk protection (Table 1). The second example was a synthesis of different preventive and curative health interventions from several analyses, reporting the cost, health benefits and financial risk protection of the interventions (Table 2). The third example looked at both government policy interventions and nongovernmental platforms for improving access to surgical cancer care in Uganda in terms of cost, deaths averted, cases of impoverishment averted and equity (Table 3).
Table 1

Extended cost–effectiveness analysis of policy interventions to increase access to surgery in rural Ethiopia

InterventionCost, US$No. of deaths avertedNo. of cases of impoverishment averted
Universal public finance945 31322.99360.71
Universal public finance + vouchers5 516 09258.642 646.68
Task-shifting401 491252.55−578.43
Universal public finance + task-shifting2 354 435289.12−231.17
Universal public finance + task-shifting + vouchers9 705 724327.512 646.68
Task-shifting + vouchers3 201 492278.06−372.65

US$: United States dollars.

Notes: The data are from a previously published study and were used to test the health-adapted superefficiency data envelopment analysis method, producing the policy ranking shown in Table 4. As defined in the original paper, universal public finance refers to making surgery free at the point of care. Task-shifting refers to training non-surgeons to provide a limited bundle of surgical services. Vouchers refer to issuing patients with vouchers for the non-medical costs of care.

Table 2

Extended cost–effectiveness analysis of various unrelated preventive and curative health interventions in Ethiopia

InterventionGovernment expenditure, US$ × 1 000 Household expenditure averted, US$ × 1 000No. of deaths avertedNo. of cases of impoverishment averted
Rotavirus vaccine800180510270
Pneumococcal vaccine1 2001101 700170
Measles vaccine260989014
Diarrhoea treatment50 00026 0003 60040 000
Pneumonia treatment31 00015 0004 10023 000
Malaria treatment670300410460
Caesarean section420270590410
Tuberculosis treatment6 9004 4002 6006 700
Hypertension treatment1 3007301401 100

US$: United States dollars.

Notes: The data are from a previously published study and were used to test the health-adapted superefficiency data envelopment analysis method, producing the policy ranking shown in Table 5.

Table 3

Extended cost–effectiveness analysis of various government and nongovernmental interventions for delivery of surgical cancer care in Uganda

InterventionCost, US$ per 100 000 populationNo. of deaths averted per 100 000 populationNo. of cases of impoverishment averted per 100 000 populationNo. of cases of catastrophic expense averted per 100 000 populationaEquity scorea
Universal public finance3 3203.00.74.2−0.08
Task-shifting3013.2−8.1−34.8−0.16
Universal public finance + task-shifting3 6708.7−1.8−23.1−0.24
Universal public finance + vouchers24 47030.7123.8218.60.24
Task-shifting + vouchers13 70118.718.057.1−0.05
Universal public finance + task-shifting + vouchers25 00933.6127.2218.60.23
Two-week mission trip40 4381.52.47.20.23
Mobile surgical unit7 04742.8106.699.40.19
Cancer hospital54 43130.374.981.20.13

US$: United States dollars.

a Equity scores were scaled from 1 (most favourable to poorer patients) to −1 (most favourable to richer patients).

Notes: The data were from a previously published study and were used to test the health-adapted superefficiency data envelopment analysis method, producing the policy ranking shown in Table 6. As defined in the original paper, universal public finance refers to making surgery free at the point of care. Task-shifting refers to training non-surgeons to provide a limited bundle of surgical services. Vouchers refer to issuing patients with vouchers for the nonmedical costs of care. Two-week surgical mission trips and the construction of a cancer hospital are self-explanatory. The modelled mobile surgical unit travelled around Uganda providing surgery at locations not served by a hospital.

US$: United States dollars. Notes: The data are from a previously published study and were used to test the health-adapted superefficiency data envelopment analysis method, producing the policy ranking shown in Table 4. As defined in the original paper, universal public finance refers to making surgery free at the point of care. Task-shifting refers to training non-surgeons to provide a limited bundle of surgical services. Vouchers refer to issuing patients with vouchers for the non-medical costs of care. US$: United States dollars. Notes: The data are from a previously published study and were used to test the health-adapted superefficiency data envelopment analysis method, producing the policy ranking shown in Table 5. US$: United States dollars. a Equity scores were scaled from 1 (most favourable to poorer patients) to −1 (most favourable to richer patients). Notes: The data were from a previously published study and were used to test the health-adapted superefficiency data envelopment analysis method, producing the policy ranking shown in Table 6. As defined in the original paper, universal public finance refers to making surgery free at the point of care. Task-shifting refers to training non-surgeons to provide a limited bundle of surgical services. Vouchers refer to issuing patients with vouchers for the nonmedical costs of care. Two-week surgical mission trips and the construction of a cancer hospital are self-explanatory. The modelled mobile surgical unit travelled around Uganda providing surgery at locations not served by a hospital. Since the purpose of this paper was not the validation of prior analyses, we did not repeat any of these cost‒effectiveness analyses; they were used as examples rather than outcomes of this paper. Similarly, the underlying assumptions in these original papers (for example, that health, financial risk protection and equity may be mutually exclusive) were not tested in this paper. They were, as with all the results used as examples, and were taken at face value. We compared the results of the new method with two existing methods: traditional cost‒effectiveness analysis (which incorporates only costs and health benefits); and standard data envelopment analysis. Analysis was performed in R software, version 3.0 (R Foundation for Statistical Computing, Vienna, Austria). Institutional review board approval was not required, because the analysis used previously published data.

Results

Comparing related policies

Table 4 shows the results of applying the three decision-making tools to the analysis of policies to increase access to surgery (Table 1). Traditional cost‒effectiveness analysis would rule out three of the policies (universal public finance, task-shifting plus vouchers for non-medical costs and universal public finance plus vouchers), because they are dominated by other policies, that is, other policies are both less expensive and more effective. Of the remaining policies, a combination of universal public finance plus task-shifting plus vouchers had the least attractive cost‒benefit ratio: over US$ 190 000 per death averted. Standard data envelopment analysis was uninformative: all except one policy (task-shifting plus vouchers) had the maximal value of 1.
Table 4

Comparison of three decision-making tools to determine the value of policy interventions to increase access to surgery

InterventionIncremental cost–effectiveness ratioaData envelopment analysis scoreHealth-adapted superefficiency data envelopment analysis score
Universal public financeDominated1.005.84
Task-shiftingDominated1.001.76
Universal public finance + task-shiftingUS$ 1 590 per death averted1.005.38
Universal public finance + vouchers US$ 53 396 per death averted1.001.98
Task-shifting+ vouchers US$ 191 515 per death averted1.006.59
Universal public finance + task-shifting + vouchersDominated0.670.67

US$: United States dollars.

a A policy is dominated when another policy is both cheaper and more effective.

Notes: We applied the three data analysis methods to a previously published extended cost–effectiveness analysis of various policies to improve access to surgery in Ethiopia (Table 1). Cost–effectiveness analysis would preclude three policies as dominated. Data envelopment analysis would not give any guidance on how to decide among the six proposed policies. Health-adapted superefficiency data envelopment analysis provides a complete ranking of policies.

US$: United States dollars. a A policy is dominated when another policy is both cheaper and more effective. Notes: We applied the three data analysis methods to a previously published extended cost–effectiveness analysis of various policies to improve access to surgery in Ethiopia (Table 1). Cost–effectiveness analysis would preclude three policies as dominated. Data envelopment analysis would not give any guidance on how to decide among the six proposed policies. Health-adapted superefficiency data envelopment analysis provides a complete ranking of policies. By contrast, health-adapted superefficiency data envelopment analysis allowed the policies to be ranked from highest (value score: 6.59) to lowest value (score: 0.67), incorporating both the health and the financial protective effects of these policies. When these effects were included in the decision, the combination of all three policies (universal public finance plus task-shifting plus vouchers) provided the best value for the combination of health and financial risk protection (score: 6.59). The next best policies were universal public finance alone (score: 5.84), which dominated in the cost‒effectiveness analysis, and task-shifting alone (score: 5.38). Task-shifting plus vouchers, which had a lower value score in the traditional data envelopment analysis (score: 0.67) had the same score under health-adapted superefficiency data envelopment analysis (score: 0.67).

Comparing unrelated policies

Table 5 demonstrates the applicability of the different decision-making tools to the evaluation of multiple, unrelated interventions (Table 2). This is a more realistic scenario than the policies in the first example, which all concerned delivery of surgical services. The second example adds a third output, household expenditures averted, to deaths averted and impoverishment averted. Again, traditional data envelopment analysis was not the most useful tool for decision-making because only three policies scored <  1 and could be ruled out (rotavirus vaccination, malaria treatment and hypertension treatment). Similarly, traditional cost‒effectiveness analysis ruled out five of the nine policies.
Table 5

Comparison of three decision-making tools to determine the value of various unrelated preventive and curative health interventions

InterventionIncremental cost–effectiveness ratioaData envelopment analysis scoreHealth-adapted superefficiency data envelopment analysis score
Rotavirus vaccineDominated0.460.46
Pneumococcal vaccineUS$ 1 160 per death averted1.002.84
Measles vaccineUS$ 2921.002.43
Diarrhoea treatmentDominated1.002.36
Pneumonia treatmentUS$ 16 067 per death averted1.002.75
Malaria treatmentDominated0.700.70
Caesarean sectionDominated1.001.51
Tuberculosis treatmentUS$ 6 333 per death averted1.001.79
Hypertension treatmentDominated0.880.88

US$: United States dollars.

a A policy is dominated when another policy is both cheaper and more effective.

Notes: We applied the three data analysis methods to a previously published extended cost–effectiveness analysis of various unrelated preventive and curative interventions in Ethiopia (Table 2). Data envelopment analysis does not give any guidance on how to decide among the nine proposed policies. Under cost–effectiveness analysis, the policy with the highest health-adapted superefficiency data envelopment analysis value has the worst incremental cost–effectiveness ratio. Health-adapted superefficiency data envelopment analysis provides a complete ranking of policies, even when the policies address different health conditions.

US$: United States dollars. a A policy is dominated when another policy is both cheaper and more effective. Notes: We applied the three data analysis methods to a previously published extended cost–effectiveness analysis of various unrelated preventive and curative interventions in Ethiopia (Table 2). Data envelopment analysis does not give any guidance on how to decide among the nine proposed policies. Under cost–effectiveness analysis, the policy with the highest health-adapted superefficiency data envelopment analysis value has the worst incremental cost–effectiveness ratio. Health-adapted superefficiency data envelopment analysis provides a complete ranking of policies, even when the policies address different health conditions. Health-adapted superefficiency data envelopment analysis allowed differentiation among the policies, ranking them from low to high value, and would therefore be more useful than the other analysis tools for prioritizing competing choices. Pneumococcal vaccination had the highest value (score: 2.84) when all outcomes were considered but had the lowest value in traditional cost‒effectiveness analysis (US$ 1160 per death averted). The next best interventions were pneumonia treatment, measles vaccine, diarrhoea treatment and tuberculosis treatment (scores: 1.79‒2.75), followed by caesarean section birth (score: 1.51).

Evaluating equity

The data for the third example, an analysis of policies to improve access to surgical cancer care (Table 3), also included two measures of financial risk protection but added a measure of equity. Table 6 shows that cost‒effectiveness rules out all but two policies (task-shifting and the mobile surgical unit). Traditional data envelopment analysis was again unhelpful for decision-making; only one policy (universal public finance for surgery plus task-shifting) scored <  1.
Table 6

Comparison of three decision-making tools to determine the value of various government and nongovernmental interventions for improving the delivery of surgical oncology services, when equity is added

InterventionIncremental cost–effectiveness ratioaData envelopment analysis scoreHealth-adapted superefficiency data envelopment analysis score
Universal public financeDominated1.002.12
Task-shiftingUS$ 94 per death averted1.0011.07
Universal public finance + task-shiftingDominated0.890.89
Universal public finance + vouchersDominated1.002.08
Task-shifting+ vouchers Dominated1.001.00
Universal public finance + task-shifting + vouchersDominated1.002.05
Two-week mission tripDominated1.001.00
Mobile surgical unitUS$ 99 per death averted1.004.82
Cancer hospitalDominated1.001.00

US$: United States dollars.

a A policy is dominated when another policy is both cheaper and more effective.

Notes: We applied the three data analysis methods to a previously published cost–effectiveness analysis of government policies and nongovernmental platforms for improving the delivery of surgical oncology services in Uganda (Table 3). Data envelopment analysis does not give any guidance on how to decide among the six proposed policies. Cost–effectiveness analysis and health-adapted superefficiency data envelopment analysis favour similar policies. Health-adapted superefficiency data envelopment analysis, however, offers a ranking of policies that appear dominated by cost–effectiveness analysis alone.

US$: United States dollars. a A policy is dominated when another policy is both cheaper and more effective. Notes: We applied the three data analysis methods to a previously published cost–effectiveness analysis of government policies and nongovernmental platforms for improving the delivery of surgical oncology services in Uganda (Table 3). Data envelopment analysis does not give any guidance on how to decide among the six proposed policies. Cost–effectiveness analysis and health-adapted superefficiency data envelopment analysis favour similar policies. Health-adapted superefficiency data envelopment analysis, however, offers a ranking of policies that appear dominated by cost–effectiveness analysis alone. Health-adapted superefficiency data envelopment analysis also ranked task-shifting (value score: 11.0) and mobile surgical units (score: 4.82) the highest, but in addition produced a clear ranking among all policies, including the dominated ones. With equity added to the equation, a decision-maker using health-adapted superefficiency data envelopment analysis would be guided towards task-shifting, given the results of the underlying extended cost‒effectiveness analysis. If this were not feasible, or in the interim while it was being scaled up, mobile surgical units might be the best choice to deliver surgical oncology care.

Discussion

In this paper, we developed and tested a method for decision-making in health policy when the population’s preferences among potential outcomes are unknown. We found that health-policy-adapted superefficiency data envelopment analysis was capable of incorporating multiple attributes and functioned better than incremental cost‒effectiveness ratios or traditional data envelopment analysis in health-policy settings. Since cost‒effectiveness analysis relies on a ratio of incremental costs over incremental health effects (measured often as disability-adjusted life-years, quality-adjusted life-years or absolute numbers of lives saved), it ignores the non-health effects of policies. As such, this common decision-making method does not fully represent the wishes of a population, a weakness that has led to counterintuitive results and, in some cases, an implicit prohibition against using ratios for decision-making altogether. In moving towards UHC, we need to look at the effects of health policies on multiple domains, including, for example, health, financial well-being and equity. The assumptions made in traditional cost‒effectiveness analysis become unsound. As this paper shows, the multi-attribute value of policy proposals is often categorically different from their cost‒effectiveness. Policies that are dominated under cost‒effectiveness analysis assumptions, and therefore declared unworthy of further study, become efficient, and sometimes the most efficient, with multi-attribute decision-making. Our method produces a rank-ordering of policies, allowing more comprehensive decisions to be made. Given that between 20% and 40% of health spending globally is wasted because of inefficiency, health-adapted superefficiency data envelopment analysis can provide valuable information to increase efficiency. Data envelopment analysis has been used to evaluate health-care delivery by facilities in various low- and middle-income countries– and management of chronic disease in American states, and even as a way to evaluate the relative merit of scientific research projects. Our new method, however, allows data envelopment analysis to be applied to policies and to be modified for health-specific contexts. Our new method has its limitations. Value, as defined by this method, can only be a proxy for decision-making. The method does not avoid the need for formal evaluations of population preferences over health improvement, financial risk protection and equity. These evaluations are difficult to perform, however, and this new method of analysis allows health policy choices to be made in the absence of quantitative evidence on patient preferences. In addition, only quantitative inputs and outputs can be considered in this new method. Non-quantitative factors which may be important to a policy-maker, such as political will, must either be quantified or be excluded from the analysis. Finally, it is not a method for policy evaluation, but for decision-making after evaluation. Cost‒effectiveness analyses, extended and otherwise, can be employed to predict the outcomes of potential policies, but cannot by themselves guide the policy-maker in how to choose given these outcomes. We developed this new method to move from evaluation to decision-making. Since no single score can dictate policymaking, our method can be used to help guide a policy-maker as to the relative value of a proposed policy. Other, competing priorities and political realities must be balanced with these results. Despite these weaknesses, the proposed new method has many strengths for health policy decision-making. First, it allows a holistic, multidimensional evaluation of health policies. As health policies assessments begin to incorporate all three aspects of the UHC framework, the method will permit multi-attribute decision-making that can incorporate any quantifiable attribute or determinant of health. The method is not limited to health, equity and financial risk protection, as in the examples presented here. Second, the analysis is relatively easy to perform. We used R, a free and publicly available statistical software, but other software programs include add-in modules for data envelopment analysis. To facilitate use of our method, we have developed a stand-alone, free, web-based module (available at: http://markshrime.com/research-tools/). Finally, the new method does not require a judgement about the relative importance of each policy domain. Population-level preference studies are needed to quantify the how much a country’s population values health protection, cost, equity and financial risk protection. Until then, our method of analysis offers guidance for policy-makers. In conclusion, health-adapted superefficiency data envelopment analysis is an adaptable tool for decision-making in the sustainable development era. The method is a formalization of the value model in health, flexibly incorporating comprehensive factors within both outcome and input domains. As such, the method can be used in place of cost‒effectiveness analysis and other ratio methods for decision-making. This paper demonstrates that this method is not only feasible, but by providing a rank order of policies, more aptly represents the multidimensional decision-making that faces policy-makers daily.
  16 in total

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Review 3.  Cost-Effectiveness in Global Surgery: Pearls, Pitfalls, and a Checklist.

Authors:  Mark G Shrime; Blake C Alkire; Caris Grimes; Tiffany E Chao; Dan Poenaru; Stéphane Verguet
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4.  Cost-Effectiveness Analysis 2.0.

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Journal:  N Engl J Med       Date:  2017-01-19       Impact factor: 91.245

5.  From Volume to Value in Health Care: The Work Begins.

Authors:  Michael E Porter; Thomas H Lee
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6.  Trading Bankruptcy for Health: A Discrete-Choice Experiment.

Authors:  Mark G Shrime; Milton C Weinstein; James K Hammitt; Jessica L Cohen; Joshua A Salomon
Journal:  Value Health       Date:  2017-09-01       Impact factor: 5.725

7.  A Novel Approach to Measuring Efficiency of Scientific Research Projects: Data Envelopment Analysis.

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