Adriana J van Ballegooijen1, Sinony R van Putten2, Marjolein Visser2, Joline W Beulens3, Emiel O Hoogendijk4. 1. Department of Health Sciences, Amsterdam Public Health Institute, VU University, Amsterdam, The Netherlands. Electronic address: aj.vanballegooijen@vumc.nl. 2. Department of Health Sciences, Amsterdam Public Health Institute, VU University, Amsterdam, The Netherlands. 3. Department of Epidemiology and Biostatistics, Amsterdam Public Health Institute, VU University Medical Center, Amsterdam, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. 4. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Abstract
OBJECTIVE: We examined the association between vitamin K status and physical functioning over 13 years in the Longitudinal Aging Study Amsterdam. STUDY DESIGN: Longitudinal cohort study of 633 community-dwelling adults from the Longitudinal Aging Study Amsterdam (LASA) aged 55-65 years (54% women). MAIN OUTCOME MEASURES: At baseline (2002-2003), plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured with a sandwich ELISA as a marker of vitamin K status. The outcome measures handgrip strength, calf circumference, self-reported functional limitations and functional performance were obtained at baseline and four follow-up examinations. We used generalized estimating equations to determine the relationship between dp-ucMGP tertiles and the various outcome measurements after adjusting for potential confounders. The lowest dp-ucMGP tertile reflects a high vitamin K status and was the reference. RESULTS: Mean dp-ucMGP was 376 ± 233 pmol/L and mean follow-up was 11.1 years. Participants showed a decline in the outcome measures over time. Compared with the lowest tertile, the highest dp-ucMGP tertile had: lower handgrip strength, 1.1 kg (95% confidence interval (-2.1, -0.1; P-trend <0.001); smaller calf circumference, -0.5 cm (-0.9 -0.1; P-trend = 0.018); and, only among women, a 0.7-point poorer functional performance score (-1.1, -0.3; P-interaction = 0.002). Dp-ucMGP was not related to self-reported functional limitations. No interaction effects between time and dp-ucMGP were observed. CONCLUSIONS: Low vitamin K status was associated with lower handgrip strength, smaller calf circumference, and, in women only, with poorer functional performance score. A low vitamin K status was however not related to the 13-year decline in these measures.
OBJECTIVE: We examined the association between vitamin K status and physical functioning over 13 years in the Longitudinal Aging Study Amsterdam. STUDY DESIGN: Longitudinal cohort study of 633 community-dwelling adults from the Longitudinal Aging Study Amsterdam (LASA) aged 55-65 years (54% women). MAIN OUTCOME MEASURES: At baseline (2002-2003), plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured with a sandwich ELISA as a marker of vitamin K status. The outcome measures handgrip strength, calf circumference, self-reported functional limitations and functional performance were obtained at baseline and four follow-up examinations. We used generalized estimating equations to determine the relationship between dp-ucMGP tertiles and the various outcome measurements after adjusting for potential confounders. The lowest dp-ucMGP tertile reflects a high vitamin K status and was the reference. RESULTS: Mean dp-ucMGP was 376 ± 233 pmol/L and mean follow-up was 11.1 years. Participants showed a decline in the outcome measures over time. Compared with the lowest tertile, the highest dp-ucMGP tertile had: lower handgrip strength, 1.1 kg (95% confidence interval (-2.1, -0.1; P-trend <0.001); smaller calf circumference, -0.5 cm (-0.9 -0.1; P-trend = 0.018); and, only among women, a 0.7-point poorer functional performance score (-1.1, -0.3; P-interaction = 0.002). Dp-ucMGP was not related to self-reported functional limitations. No interaction effects between time and dp-ucMGP were observed. CONCLUSIONS: Low vitamin K status was associated with lower handgrip strength, smaller calf circumference, and, in women only, with poorer functional performance score. A low vitamin K status was however not related to the 13-year decline in these measures.
Authors: Marcos D Machado-Fragua; Emiel O Hoogendijk; Ellen A Struijk; Fernando Rodriguez-Artalejo; Esther Lopez-Garcia; Joline W Beulens; Adriana J van Ballegooijen Journal: Eur J Nutr Date: 2019-05-08 Impact factor: 5.614
Authors: M Kyla Shea; Stephen B Kritchevsky; Richard F Loeser; Sarah L Booth Journal: J Gerontol A Biol Sci Med Sci Date: 2020-03-09 Impact factor: 6.591