Literature DB >> 29902924

Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker.

Christopher J O'Conor1, Tiffany Chen1, Iván González1, Dengfeng Cao1, Yan Peng2.   

Abstract

Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44+/CD24- and ALDH1+ breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44+/CD24- and ALDH1+ breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.

Entities:  

Keywords:  biomarkers; breast cancer; cancer stem cells; triple-negative breast cancer

Mesh：

Year:  2018        PMID： 29902924     DOI： 10.2217/bmm-2017-0398

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  28 in total

1.  Novel insights linking BRCA1-IRIS role in mammary gland development to formation of aggressive PABCs: the case for longer breastfeeding.

Authors:  Patricia Castillo; Omonigho Aisagbonhi; Cheryl C Saenz; Wael M ElShamy
Journal:  Am J Cancer Res       Date:  2022-01-15       Impact factor: 6.166

2.  CircUBR5 acts as a ceRNA for miR-1179 to up-regulate UBR5 and to promote malignancy of triple-negative breast cancer.

Authors:  Guohua Gong; Jikai She; Danni Fu; Dong Zhen; Bin Zhang
Journal:  Am J Cancer Res       Date:  2022-06-15       Impact factor: 5.942

3.  Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis.

Authors:  Yue Yang; Yuanyuan Lu; Chunhua Zhang; Qianqian Guo; Wenzhou Zhang; Ting Wang; Zhuolu Xia; Jing Liu; Xiangyu Cheng; Tao Xi; Feng Jiang; Lufeng Zheng
Journal:  Cell Mol Life Sci       Date:  2022-06-11       Impact factor: 9.207

4.  Tumor-associated macrophages promote epithelial-mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling.

Authors:  Xiangzhou Chen; Mingqiang Yang; Jiang Yin; Pan Li; Shanshan Zeng; Guopei Zheng; Zhimin He; Hao Liu; Qian Wang; Fan Zhang; Danyang Chen
Journal:  Cell Commun Signal       Date:  2022-06-17       Impact factor: 7.525

5.  Targeting CLK4 inhibits the metastasis and progression of breast cancer by inactivating TGF-β pathway.

Authors:  Eunji Kang; Kanggeon Kim; Sook Young Jeon; Ji Gwang Jung; Hong-Kyu Kim; Han-Byoel Lee; Wonshik Han
Journal:  Cancer Gene Ther       Date:  2022-01-19       Impact factor: 5.854

Review 6.  Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response.

Authors:  Vasudeva Bhat; Alison L Allan; Afshin Raouf
Journal:  Cancers (Basel)       Date:  2019-08-24       Impact factor: 6.639

Review 7.  Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.

Authors:  Xixi Dou; Pingzhen Tong; Hai Huang; Lucas Zellmer; Yan He; Qingwen Jia; Daizhou Zhang; Jiang Peng; Chenguang Wang; Ningzhi Xu; Dezhong Joshua Liao
Journal:  J Cancer       Date:  2020-03-04       Impact factor: 4.207

8.  Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling.

Authors:  Xing Zhen; Hack Sun Choi; Ji-Hyang Kim; Su-Lim Kim; Ren Liu; Bong-Sik Yun; Dong-Sun Lee
Journal:  Biomolecules       Date:  2020-02-05

9.  Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins.

Authors:  Chanjuan Zheng; Shichao Yan; Lu Lu; Hui Yao; Guangchun He; Sisi Chen; Ying Li; Xiaojun Peng; Zhongyi Cheng; Mi Wu; Qiuting Zhang; Guifei Li; Shujun Fu; Xiyun Deng
Journal:  Front Oncol       Date:  2021-06-04       Impact factor: 6.244

10.  Therapeutic Potential of a Novel αvβ₃ Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type.

Authors:  Billy Samuel Hill; Annachiara Sarnella; Domenica Capasso; Daniela Comegna; Annarita Del Gatto; Matteo Gramanzini; Sandra Albanese; Michele Saviano; Laura Zaccaro; Antonella Zannetti
Journal:  Cancers (Basel)       Date:  2019-01-24       Impact factor: 6.639
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