| Literature DB >> 29902430 |
John F Cryan1, Gerard Clarke2, Timothy G Dinan2, Harriet Schellekens3.
Abstract
While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.Entities:
Mesh:
Year: 2018 PMID: 29902430 DOI: 10.1016/j.chom.2018.05.020
Source DB: PubMed Journal: Cell Host Microbe ISSN: 1931-3128 Impact factor: 21.023