Hajime Uno1, Dae Hyun Kim2,3, Lee-Jen Wei4. 1. Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. 2. Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 3. Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 4. Department of Biostatistics, Harvard University, Boston, Massachusetts.