Literature DB >> 29900385

In vitro studies data on anticancer activity of Caesalpinia sappan L. heartwood and leaf extracts on MCF7 and A549 cell lines.

Arunkumar Naik Bukke1, Fathima Nazneen Hadi1, K Suresh Babu2, P Chandramati Shankar1.   

Abstract

This article contains data on in vitro cytotoxicity activity of chloroform, methanolic and water extracts of leaf and heartwood of Caesalpinia sappan L. a medicinal plant against Breast cancer (MCF-7) and Lung cancer (A-549) cells. This data shows that Brazilin A, a natural bioactive compound in heartwood of Caesalpinia sappan L.induced cell death in breast cancer (MCF-7) cells. The therapeutic property was further proved by docking the Brazilin A molecule against BCL-2 protein (an apoptotic inhibitor) using auto dock tools.

Entities:  

Keywords:  A549; Caesalpinia sappan L.; Chloroform extract; Cytotoxicity; MCF7; MTT Assay; Methanol extract; Water extract

Year:  2018        PMID： 29900385      PMCID： PMC5997910          DOI： 10.1016/j.dib.2018.05.050

Source DB:  PubMed          Journal:  Data Brief        ISSN： 2352-3409


  1 in total

1.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.

Authors:  Garrett M Morris; Ruth Huey; William Lindstrom; Michel F Sanner; Richard K Belew; David S Goodsell; Arthur J Olson
Journal:  J Comput Chem       Date:  2009-12       Impact factor: 3.376
  1 in total
  6 in total

Review 1.  A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds.

Authors:  Kishor Mazumder; Biswajit Biswas; Iqbal Mahmud Raja; Koichi Fukase
Journal:  Molecules       Date:  2020-04-20       Impact factor: 4.411

2.  Proton NMR and HR-LC/MS based phytochemical analysis of methanolic fraction of Alectra parasitica A. Rich. rhizomes.

Authors:  Shriniwas P Patil
Journal:  Heliyon       Date:  2020-01-22

3.  Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression.

Authors:  Xue-Cong Zheng; Ze-Sheng Shi; Cheng-Zhi Qiu; Zhong-Shi Hong; Chun-Xiao Wang; Hai-Bin Zhuang; Zhi-Chuan Chen; Jian-Peng Pan
Journal:  Integr Cancer Ther       Date:  2020 Jan-Dec       Impact factor: 3.279

4.  Anticancer activity of Caesalpinia sappan by downregulating mitochondrial genes in A549 lung cancer cell line.

Authors:  Nashi Widodo; Sapti Puspitarini; Muhammad Hermawan Widyananda; Adzral Alamsyah; Septian Tri Wicaksono; Masruri Masruri; Yoga Dwi Jatmiko
Journal:  F1000Res       Date:  2022-02-11

5.  Integrative Bioinformatics Analysis Reveals Potential Target Genes and TNFα Signaling Inhibition by Brazilin in Metastatic Breast Cancer Cells.

Authors:  Adam Hermawan; Herwandhani Putri
Journal:  Asian Pac J Cancer Prev       Date:  2020-09-01

6.  Anticancer, Antioxidant, and Antibacterial Activities of the Methanolic Extract from Sphagneticola trilobata (L.) J. F Pruski Leaves.

Authors:  Vivi Mardina; Syafruddin Ilyas; Halimatussakdiah Halimatussakdiah; Tisna Harmawan; Masitta Tanjung; Faridah Yusof
Journal:  J Adv Pharm Technol Res       Date:  2021-07-16
  6 in total

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