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Literature DB >> 2990038

Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle.

T Nelson, G Lucignani, S Atlas, A M Crane, G A Dienel, L Sokoloff.

Abstract

Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.

Entities: Chemical Gene Species

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Year: 1985 PMID： 2990038 DOI： 10.1126/science.2990038

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

18 in total

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Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle.

Review 1. Noninvasive measurement of brain glycogen by nuclear magnetic resonance spectroscopy and its application to the study of brain metabolism.

2. Immunohistochemical demonstration of glycogen phosphorylase in rat brain slices.

3. The effect of pretreatment with pentobarbital on the extent of [14C] incorporation from [U-14C]glucose into various rat brain glycolytic intermediates: relevance to regulation at hexokinase and phosphofructokinase.

Review 4. Does fluorine-18 fluorodeoxyglucose metabolic imaging of tumours benefit oncology?

Review 5. A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra.

6. FDG transport and phosphorylation in human gliomas measured with dynamic PET.

Review 7. In Vivo NMR Studies of the Brain with Hereditary or Acquired Metabolic Disorders.

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9. Astrocytic glucose-6-phosphatase and the permeability of brain microsomes to glucose 6-phosphate.

Review 10. Contributions of glycogen to astrocytic energetics during brain activation.