Literature DB >> 29899001

Performance of Chlamydia trachomatis OmcB Enzyme-Linked Immunosorbent Assay in Serodiagnosis of Chlamydia trachomatis Infection in Women.

Kanupriya Gupta1, LaDraka' Brown1, Rakesh K Bakshi1, Christen G Press1, Xiaofei Chi2, Rachel J Gorwitz3, John R Papp3, William M Geisler4.   

Abstract

Chlamydia trachomatis serological assays with improved sensitivity over commercially available assays are needed to evaluate the burden of C. trachomatis infection and the effectiveness of prevention efforts. We evaluated the performance of a C. trachomatis outer membrane complex protein B (OmcB) enzyme-linked immunosorbent assay (ELISA) in the detection of anti-C. trachomatis antibody responses in C. trachomatis-infected women. OmcB ELISA was less sensitive than our C. trachomatis elementary body (EB) ELISA, but it was highly specific. The magnitude of the antibody response was higher in African-Americans and those with prior C. trachomatis infection. Unlike EB ELISA, the IgG1 response to C. trachomatis OmcB was short-lived and was not maintained by repeat C. trachomatis infection.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Chlamydia trachomatis; ELISA; OmcB

Mesh：

Substances：

Year:  2018        PMID： 29899001      PMCID： PMC6113486          DOI： 10.1128/JCM.00275-18

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  26 in total

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9.  Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes.

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4.  Prevalence of Chlamydia trachomatis Infection in Young Women and Associated Predictors.

Authors:  Kanupriya Gupta; Sally A Harrison; Nkele A Davis; Matilda L Culp; Samuel C Hand; Tina Simpson; Barbara Van Der Pol; James W Galbraith; Nicholas J Van Wagoner; Sandra G Morrison; Richard P Morrison; William M Geisler
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  4 in total

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