G Salunkhe1, K Weissbrodt1, B Feige2, C W N Saville3, A Berger4, N M Dundon1, S Bender5, N Smyrnis6, A Beauducel7, M Biscaldi1, C Klein1,5. 1. Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Freiburg, Germany. 2. Department of Psychiatry and Psychotherapy, Medical Faculty, University of Freiburg, Germany. 3. School of Psychology, Bangor University, UK. 4. Department of Psychology and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel. 5. Department of Child and Adolescent Psychiatry, Medical Faculty, University of Cologne, Germany. 6. Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Greece. 7. Department for Research Methods, Diagnostics and Evaluation, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Abstract
Objective: Recent discussions of aetiological overlap between ADHD and Autism Spectrum Disorder (ASD) require comparative studying of these disorders. METHOD: We examined performance of ASD patients with (ASD+) and without (ASD-) comorbid ADHD, ADHD patients, and controls for selected putative endophenotypes of ADHD: Intrasubject Variability (ISV) of reaction times, working memory (WM), inhibition, and temporal processing. RESULTS: We found that patients with ADHD or ASD+, but not ASD-, had elevated ISV across the entire task battery and temporal processing deficits, and that none of the groups were impaired in WM or inhibition. High levels of ISV and generally poor performance in ASD+ patients were only partially due to additive effects of the pure disorders. CONCLUSION: Overall, we conclude that, within our limited but heterogeneous task battery, ISV and temporal processing deficits are most sensitive to ADHD symptomatology and that controlling for ADHD comorbidity is mandatory when assessing ISV in autism.
Objective: Recent discussions of aetiological overlap between ADHD and Autism Spectrum Disorder (ASD) require comparative studying of these disorders. METHOD: We examined performance of ASDpatients with (ASD+) and without (ASD-) comorbid ADHD, ADHDpatients, and controls for selected putative endophenotypes of ADHD: Intrasubject Variability (ISV) of reaction times, working memory (WM), inhibition, and temporal processing. RESULTS: We found that patients with ADHD or ASD+, but not ASD-, had elevated ISV across the entire task battery and temporal processing deficits, and that none of the groups were impaired in WM or inhibition. High levels of ISV and generally poor performance in ASD+ patients were only partially due to additive effects of the pure disorders. CONCLUSION: Overall, we conclude that, within our limited but heterogeneous task battery, ISV and temporal processing deficits are most sensitive to ADHD symptomatology and that controlling for ADHD comorbidity is mandatory when assessing ISV in autism.
Entities:
Keywords:
endophenotypes; intrasubject variability; response inhibition; temporal reproduction; working memory
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