| Literature DB >> 2989698 |
C J March, B Mosley, A Larsen, D P Cerretti, G Braedt, V Price, S Gillis, C S Henney, S R Kronheim, K Grabstein.
Abstract
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.Entities:
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Year: 1985 PMID： 2989698 DOI： 10.1038/315641a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962