Manisha Kumar1, Vandana Jha1, Anuradha Singh1. 1. Professor, Department of Obstetrics and Gynaecology, Lady Hardinge Medical College, Bhagat Singh Marg, New Delhi, 110001 India.
Abstract
AIMS AND OBJECTIVE: To evaluate the cause of NIHF cases referred to a tertiary referral center and to analyze the outcome. MATERIALS AND METHODS: A total of 130 cases of fetal hydrops registered during eight-year study period were reviewed. Antenatal ultrasound, blood investigations and postnatal fetal examination were done, and outcome was noted. RESULTS: Out of 130 cases of NIHF, antenatal ultrasound showed the presence of structural malformations in 94/130 (72.3%), cardiac abnormality was the most common (34/130, 26.1%) and cystic hygroma was seen in 15/130 (11.5%). Chromosomal abnormality was observed in 15(11.5%) cases, and Doppler US showed anemia in 4/130 (3.1%) cases only. Live born were 25 (12.9%), and rest all were stillborn or abortion. Later mean gestational age of presentation (p = 0.0001), presence of gastrointestinal malformation (p = 0.0001) and absence of structural malformations (p = 0.0441) were factors significantly associated with live birth; the presence of cystic hygroma (p = 0.0431) or structural heart defect (p = 0.007) was significantly associated with poor outcome. CONCLUSION: Fetal anemia was not a common cause of NIHF in the study population. The early onset of hydrops and presence of structural malformation carry a graver prognosis; type of structural defect also has bearing on outcome.
AIMS AND OBJECTIVE: To evaluate the cause of NIHF cases referred to a tertiary referral center and to analyze the outcome. MATERIALS AND METHODS: A total of 130 cases of fetal hydrops registered during eight-year study period were reviewed. Antenatal ultrasound, blood investigations and postnatal fetal examination were done, and outcome was noted. RESULTS: Out of 130 cases of NIHF, antenatal ultrasound showed the presence of structural malformations in 94/130 (72.3%), cardiac abnormality was the most common (34/130, 26.1%) and cystic hygroma was seen in 15/130 (11.5%). Chromosomal abnormality was observed in 15(11.5%) cases, and Doppler US showed anemia in 4/130 (3.1%) cases only. Live born were 25 (12.9%), and rest all were stillborn or abortion. Later mean gestational age of presentation (p = 0.0001), presence of gastrointestinal malformation (p = 0.0001) and absence of structural malformations (p = 0.0441) were factors significantly associated with live birth; the presence of cystic hygroma (p = 0.0431) or structural heart defect (p = 0.007) was significantly associated with poor outcome. CONCLUSION: Fetal anemia was not a common cause of NIHF in the study population. The early onset of hydrops and presence of structural malformation carry a graver prognosis; type of structural defect also has bearing on outcome.
Authors: Carlo Bellini; Raoul C M Hennekam; Ezio Fulcheri; Mariangela Rutigliani; Guido Morcaldi; Francesco Boccardo; Eugenio Bonioli Journal: Am J Med Genet A Date: 2009-05 Impact factor: 2.802
Authors: Carlo Bellini; Gloria Donarini; Dario Paladini; Maria Grazia Calevo; Tommaso Bellini; Luca A Ramenghi; Raoul C Hennekam Journal: Am J Med Genet A Date: 2015-02-25 Impact factor: 2.802