Literature DB >> 2989517

Isoxazoles with antipicornavirus activity.

G D Diana, M A McKinlay, C J Brisson, E S Zalay, J V Miralles, U J Salvador.   

Abstract

The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.

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Year:  1985        PMID： 2989517     DOI： 10.1021/jm00383a010

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  12 in total

Review 1.  Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.

Authors:  Anna Egorova; Sean Ekins; Michaela Schmidtke; Vadim Makarov
Journal:  Eur J Med Chem       Date:  2019-06-11       Impact factor: 6.514

2.  The pentamer channel stiffening model for drug action on human rhinovirus HRV-1A.

Authors:  N Vaidehi; W A Goddard
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

3.  SCH 48973: a potent, broad-spectrum, antienterovirus compound.

Authors:  P J Buontempo; S Cox; J Wright-Minogue; J L DeMartino; A M Skelton; E Ferrari; R Albin; E J Rozhon; V Girijavallabhan; J F Modlin; J F O'Connell
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

4.  Antirhinovirus activity of purine nucleoside analogs.

Authors:  E De Clercq; R Bernaerts; D E Bergstrom; M J Robins; J A Montgomery; A Holy
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191

5.  3-(4-Chloro-phen-yl)-7-methyl-4-(4-methyl-phen-yl)-1-oxa-2,7-diaza-spiro-[4.5]dec-2-en-10-one.

Authors:  D Gayathri; D Velmurugan; R Ranjith Kumar; S Perumal; K Ravikumar
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-09

6.  (5S,6S,10R)-10-(2,4-Dichloro-phen-yl)-14-[(E)-(2,4-dichloro-phen-yl)methyl-idene]-3,9-diphenyl-12-[(R)-1-phenyl-ethyl]-1,4,7-trioxa-2,8,12-triaza-dispiro-[4.0.4.4]tetra-deca-2,8-diene.

Authors:  S Mahalakshmi; R Suresh Kumar; S Perumal; V Sivakumar; J Suresh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

7.  Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships.

Authors:  Yan Lu; Chien-Ming Li; Zhao Wang; Charles R Ross; Jianjun Chen; James T Dalton; Wei Li; Duane D Miller
Journal:  J Med Chem       Date:  2009-03-26       Impact factor: 7.446

8.  In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.

Authors:  Céline Lacroix; Samuela Laconi; Fabrizio Angius; Antonio Coluccia; Romano Silvestri; Raffaello Pompei; Johan Neyts; Pieter Leyssen
Journal:  Virol J       Date:  2015-07-14       Impact factor: 4.099

Review 9.  Picornavirus inhibitors.

Authors:  L Carrasco
Journal:  Pharmacol Ther       Date:  1994       Impact factor: 12.310

10.  Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives.

Authors:  Asma Alshamari; Mahmoud Al-Qudah; Fedaa Hamadeh; Lo'ay Al-Momani; Sultan Abu-Orabi
Journal:  Molecules       Date:  2020-09-18       Impact factor: 4.411
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