Hussain Gadelkarim Ahmed1, Rania Saad A Suliman2, Ibraheem M Ashankyty3, Zaid Ali Albieh4, Aymen A Warille5. 1. Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan. 2. Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology, Khartoum, Sudan. 3. Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Kingdom of Saudi Arabia. 4. Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia. 5. Department of Anatomy and Histology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia.
Abstract
OBJECTIVE: The purpose of this study was to identify human Cytomegalovirus (HCMV) in tissue blocks obtained from patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: Formalin-fixed paraffin wax processed NPC tissue were obtained from 150 tissue blocks and retrospectively investigated for the presence of HCMV using polymerase chain reaction. RESULTS: Of the 150 NPC tissue specimens, HCMV was identified in 53/150 (35.3%) of the samples. Out of the 53 samples infected with HCMV, 33/97 (34%) were among males and 20/53 (37.7%) were among females. Of the 53 positive samples, 36/53 (68%) were found to harbor Epstein-Barr virus (EBV). CONCLUSION: The present study has shown a relatively considerable association between HCMV and NPC. The great majority of samples sheltering HCMV were also found to hide EBV, which proposes the potentiality of EBV over HCMV.
OBJECTIVE: The purpose of this study was to identify human Cytomegalovirus (HCMV) in tissue blocks obtained from patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: Formalin-fixed paraffin wax processed NPC tissue were obtained from 150 tissue blocks and retrospectively investigated for the presence of HCMV using polymerase chain reaction. RESULTS: Of the 150 NPC tissue specimens, HCMV was identified in 53/150 (35.3%) of the samples. Out of the 53 samples infected with HCMV, 33/97 (34%) were among males and 20/53 (37.7%) were among females. Of the 53 positive samples, 36/53 (68%) were found to harbor Epstein-Barr virus (EBV). CONCLUSION: The present study has shown a relatively considerable association between HCMV and NPC. The great majority of samples sheltering HCMV were also found to hide EBV, which proposes the potentiality of EBV over HCMV.
Entities:
Keywords:
Human Cytomegalovirus; Sudan; nasopharyngeal carcinoma