| Literature DB >> 29893126 |
Fan Wu1, Ming Zhang2,3, Hanwen Lu1, Dong Liang1, Yaliang Huang1, Yonghong Xia1, Yuqing Hu1, Shengqiang Hu1, Jianxiu Wang1, Xinyao Yi1, Jun Zhang2,3.
Abstract
The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(γ-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (Fe3O4) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy. The biodistribution of nanoparticles was investigated by magnetic resonance imaging. Experiments in vivo confirm the efficient accumulations of nanoparticles at tumor sites. Meanwhile, tumor growth was effectively inhibited via synergistic photothermal/chemotherapy with minimal side effects.Entities:
Keywords: MHPCNs; MR imaging; PGA; synergistic photothermal/chemo-therapy; triple-responsive
Mesh：
Substances：
Year: 2018 PMID： 29893126 DOI： 10.1021/acsami.8b07213
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229