Literature DB >> 29891612

Tet38 Efflux Pump Contributes to Fosfomycin Resistance in Staphylococcus aureus.

Q C Truong-Bolduc1, Y Wang1, D C Hooper2.   

Abstract

Fosfomycin inhibits MurA following uptake by the GlpT transporter of glycerol-3-phosphate in Escherichia coli In Staphylococcus aureus, plasmid overexpression of the Tet38 efflux pump and a glpT mutant resulted in increased MICs and decreased accumulation of fosfomycin, with MICs affected by glycerol-3-phosphate. In contrast, a tet38 mutant had a lower MIC and increased accumulation of fosfomycin, suggesting that Tet38 acts as an efflux transporter of fosfomycin.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  G3P; S. aureus; Tet38; efflux pump; fosfomycin

Mesh：

Substances：

Year:  2018        PMID： 29891612      PMCID： PMC6105802          DOI： 10.1128/AAC.00927-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Review 6.  Glycerol-3-phosphate transporter of Escherichia coli: structure, function and regulation.

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7.  Elevated Expression of GlpT and UhpT via FNR Activation Contributes to Increased Fosfomycin Susceptibility in Escherichia coli under Anaerobic Conditions.

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9.  Mutations of the Transporter Proteins GlpT and UhpT Confer Fosfomycin Resistance in Staphylococcus aureus.

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  5 in total

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2.  Role of Staphylococcus aureus Tet38 in Transport of Tetracycline and Its Regulation in a Salt Stress Environment.

Authors:  Q C Truong-Bolduc; Y Wang; D C Hooper
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Authors:  Q C Truong-Bolduc; Y Wang; D C Hooper
Journal:  Infect Immun       Date:  2021-04-16       Impact factor: 3.441

4.  Mechanisms of high-level fosfomycin resistance in Staphylococcus aureus epidemic lineage ST5.

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Review 5.  Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition.

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  5 in total

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