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Literature DB >> 29891601

Potency of Solithromycin against Fast- and Slow-Growing Chlamydial Organisms.

Leiqiong Gao^1,2, Yao Wang³, Ziyu Hua³, Enmei Liu¹, Li Shen⁴.

Abstract

Evidence is provided that solithromycin is a bactericidal against not only fast-growing chlamydial organisms but also those slowed by gamma interferon (IFN-γ) in vitro At sublethal concentrations, Sol impedes homotypic fusion of Chlamydia-containing vacuoles and reduces secretion of the type III secretion (T3S) effector IncA. Sol may therefore represent a potential new clinical treatment for Chlamydia infections. Selective perturbation of the T3S system suggests a novel mode of antibacterial action for Sol that warrants further investigation.

Entities: Chemical Disease Gene

Keywords: Chlamydia trachomatis; antibacterial mechanism; bacterial translation; gamma interferon; green fluorescent protein; obligate intracellular bacterium; persistent infection; productive infection; solithromycin; type III secretion system

Mesh：

Substances：

Year: 2018 PMID： 29891601 PMCID： PMC6105862 DOI： 10.1128/AAC.00588-18

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

31 in total

1. Novel Detection Strategy To Rapidly Evaluate the Efficacy of Antichlamydial Agents.

Authors: Yan Zhang; Yuqi Xian; Leiqiong Gao; Hiba Elaasar; Yao Wang; Lamiya Tauhid; Ziyu Hua; Li Shen
Journal: Antimicrob Agents Chemother Date: 2017-01-24 Impact factor: 5.191

2. The Chlamydia trachomatis IncA protein is required for homotypic vesicle fusion.

Authors: T Hackstadt; M A Scidmore-Carlson; E I Shaw; E R Fischer
Journal: Cell Microbiol Date: 1999-09 Impact factor: 3.715

3. Andrographolide inhibits intracellular Chlamydia trachomatis multiplication and reduces secretion of proinflammatory mediators produced by human epithelial cells.

Authors: Ziyu Hua; Kyla M Frohlich; Yan Zhang; Xiaogeng Feng; Jiaxing Zhang; Li Shen
Journal: Pathog Dis Date: 2014-12-17 Impact factor: 3.166

Review 4. Disulfide cross-linked envelope proteins: the functional equivalent of peptidoglycan in chlamydiae?

Authors: T P Hatch
Journal: J Bacteriol Date: 1996-01 Impact factor: 3.490

5. Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

Authors: Thomas M File; Paul B Eckburg; George H Talbot; Lily Llorens; H David Friedland
Journal: Int J Antimicrob Agents Date: 2017-06-06 Impact factor: 5.283

6. Surveillance of the activity of solithromycin (CEM-101) against bacteria from respiratory tract infections.

Authors: Stephen Hawser; Ian Morrissey; Barbara Lemos; Kara Keedy; Prabhavathi Fernandes
Journal: Int J Antimicrob Agents Date: 2017-05-05 Impact factor: 5.283

7. A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit.

Authors: Xiancai Rao; Padraig Deighan; Ziyu Hua; Xiaomei Hu; Jin Wang; Miao Luo; Jie Wang; Yanmei Liang; Guangming Zhong; Ann Hochschild; Li Shen
Journal: Genes Dev Date: 2009-08-01 Impact factor: 11.361

Potency of Solithromycin against Fast- and Slow-Growing Chlamydial Organisms.

1. Novel Detection Strategy To Rapidly Evaluate the Efficacy of Antichlamydial Agents.

2. The Chlamydia trachomatis IncA protein is required for homotypic vesicle fusion.

3. Andrographolide inhibits intracellular Chlamydia trachomatis multiplication and reduces secretion of proinflammatory mediators produced by human epithelial cells.

Review 4. Disulfide cross-linked envelope proteins: the functional equivalent of peptidoglycan in chlamydiae?

5. Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

6. Surveillance of the activity of solithromycin (CEM-101) against bacteria from respiratory tract infections.

7. A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit.

8. Chlamydia public health programs and the epidemiology of pelvic inflammatory disease and ectopic pregnancy.

9. Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence.

10. Structure of a bacterial type III secretion system in contact with a host membrane in situ.

1. Context-Dependent Action of Scc4 Reinforces Control of the Type III Secretion System.