Grzegorz Łabuz1, Timur M Yildirim2, Thomas J T P van den Berg2, Ramin Khoramnia2, Gerd U Auffarth2. 1. From the David J. Apple Center for Vision Research, Department of Ophthalmology (Łabuz, Yildirim, Khoramnia, Auffarth), University Hospital Heidelberg, Heidelberg, Germany; the Netherlands Institute for Neuroscience (van den Berg), Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. Electronic address: g.labuz@hotmail.com. 2. From the David J. Apple Center for Vision Research, Department of Ophthalmology (Łabuz, Yildirim, Khoramnia, Auffarth), University Hospital Heidelberg, Heidelberg, Germany; the Netherlands Institute for Neuroscience (van den Berg), Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Abstract
PURPOSE: To assess the optical quality of intraocular lenses (IOLs) explanted because of opacification after the intraocular injection of gas. SETTING: David J. Apple Laboratory, Heidelberg, Germany. DESIGN: Experimental study. METHODS: Four hydrophilic acrylic IOLs were studied, each with a centrally localized round opacification pattern associated with the intraocular use of gas. Laboratory analysis included gross examination with a light microscope, followed by alizarin and von Kossa staining. Optical quality was assessed by examining the modulation transfer function (MTF) and straylight. Results were compared with those of a control IOL and normative data for straylight of the crystalline lens. The following parameters were derived from image analysis: opacified surface fraction, light loss in the opacified surface, and the area and number of granules. The relationship between straylight increase and those parameters was studied. RESULTS: Fine granules were identified on the IOL surface and subsurface. The granules stained positive for calcium, and the MTF levels of 2 IOLs dropped markedly. The other 2 showed relatively minor changes. The straylight was extremely increased in 3 IOLs up to (and above) a level of that of a cataractous lens. A proportional relationship was found between straylight and the morphological parameters from image analysis. CONCLUSIONS: Intraocular lenses with centrally localized opacification have a strong potential for deteriorating optical performance. However, the optical quality might differ depending on the morphology of opacification. A serious straylight increase was found in most of these IOLs, suggesting that affected patients may suffer from glare-related symptoms.
PURPOSE: To assess the optical quality of intraocular lenses (IOLs) explanted because of opacification after the intraocular injection of gas. SETTING: David J. Apple Laboratory, Heidelberg, Germany. DESIGN: Experimental study. METHODS: Four hydrophilic acrylic IOLs were studied, each with a centrally localized round opacification pattern associated with the intraocular use of gas. Laboratory analysis included gross examination with a light microscope, followed by alizarin and von Kossa staining. Optical quality was assessed by examining the modulation transfer function (MTF) and straylight. Results were compared with those of a control IOL and normative data for straylight of the crystalline lens. The following parameters were derived from image analysis: opacified surface fraction, light loss in the opacified surface, and the area and number of granules. The relationship between straylight increase and those parameters was studied. RESULTS: Fine granules were identified on the IOL surface and subsurface. The granules stained positive for calcium, and the MTF levels of 2 IOLs dropped markedly. The other 2 showed relatively minor changes. The straylight was extremely increased in 3 IOLs up to (and above) a level of that of a cataractous lens. A proportional relationship was found between straylight and the morphological parameters from image analysis. CONCLUSIONS: Intraocular lenses with centrally localized opacification have a strong potential for deteriorating optical performance. However, the optical quality might differ depending on the morphology of opacification. A serious straylight increase was found in most of these IOLs, suggesting that affected patients may suffer from glare-related symptoms.
Authors: Marc Mackert; Daniel Rudolf Muth; Efstathios Vounotrypidis; Constanze Deger; David Goldblum; Mehdi Shajari; Pascal Willy Hasler; Siegfried Priglinger; Armin Wolf Journal: BMJ Open Ophthalmol Date: 2021-02-11
Authors: Hyeck Soo Son; Grzegorz Labuz; Ramin Khoramnia; Patrick Merz; Timur M Yildirim; Gerd U Auffarth Journal: PLoS One Date: 2020-02-04 Impact factor: 3.240