Literature DB >> 2988862

Chromosomal site of hepatitis B virus (HBV) integration in a human hepatocellular carcinoma-derived cell line.

D Simon, D B Searls, Y Cao, K Sun, B B Knowles.   

Abstract

The single site of integration of hepatitis B virus in the human hepatocellular carcinoma cell line Hep 3B 2-1/7 was found to segregate with human chromosome 12 in somatic cell hybrids. Analysis of metaphase spreads of Hep 3B 2-1/7 following in situ hybridization with pHBV revealed integration at 12q13----q14, a location that coincides with a fragile site, fra (12q13). The possible significance of this location to the development of hepatocellular carcinomas is discussed.

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Year:  1985        PMID： 2988862     DOI： 10.1159/000132118

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  3 in total

1.  Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

Authors:  C R Carlin; D Simon; J Mattison; B B Knowles
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

2.  Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

Authors:  B Bressac; K M Galvin; T J Liang; K J Isselbacher; J R Wands; M Ozturk
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

3.  Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.

Authors:  T Tokino; K Matsubara
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103
  3 in total

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