Literature DB >> 2988808

Cellular recovery of dividing and confluent C3H10T1/2 cells from N-methyl-N'-nitro-N-nitrosoguanidine in the presence of ADP-ribosylation inhibitors.

E L Jacobson, J Y Smith, K Wielckens, H Hilz, M K Jacobson.   

Abstract

The relationship between treatment with 3-methoxy-benzamide (MBA), a potent inhibitor of ADP-ribosylation reactions, and the response of C3H10T1/2 cells to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) has been examined. Quiescent cells effected potentially lethal damage repair (PLDR) over a 48-h period following MNNG and the repair was coincident with the removal of DNA strand breaks. MBA had no effect on PLDR but was very co-cytotoxic with MNNG in dividing cells. The presence of MBA caused the appearance of an additional number of DNA strand breaks following MNNG in both quiescent and dividing cells. These results suggest that ADP-ribosylation is required for normal cell cycle progression following DNA damage in dividing cells.

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Year:  1985        PMID： 2988808     DOI： 10.1093/carcin/6.5.715

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  9 in total

1.  Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.

Authors:  David W Koh; Ann M Lawler; Marc F Poitras; Masayuki Sasaki; Sigrid Wattler; Michael C Nehls; Tobias Stöger; Guy G Poirier; Valina L Dawson; Ted M Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-10       Impact factor: 11.205

2.  trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon.

Authors:  J H Küpper; M Müller; M K Jacobson; J Tatsumi-Miyajima; D L Coyle; E L Jacobson; A Bürkle
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

3.  Growth-phase-dependent response to DNA damage in poly(ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in DNA replication and repair.

Authors:  S Chatterjee; N A Berger
Journal:  Mol Cell Biochem       Date:  1994-09       Impact factor: 3.396

4.  Poly(ADP-ribose) polymerase: a guardian of the genome that facilitates DNA repair by protecting against DNA recombination.

Authors:  S Chatterjee; S J Berger; N A Berger
Journal:  Mol Cell Biochem       Date:  1999-03       Impact factor: 3.396

5.  Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis.

Authors:  E L Jacobson; W M Shieh; A C Huang
Journal:  Mol Cell Biochem       Date:  1999-03       Impact factor: 3.396

6.  Evolving Role of Immunotherapy in Metastatic Castration Refractory Prostate Cancer.

Authors:  Nityam Rathi; Taylor Ryan McFarland; Roberto Nussenzveig; Neeraj Agarwal; Umang Swami
Journal:  Drugs       Date:  2021-02       Impact factor: 9.546

7.  Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy.

Authors:  Xiaoxing Feng; Yiran Zhou; Alicia M Proctor; Mandi M Hopkins; Mengwei Liu; David W Koh
Journal:  Mol Cancer       Date:  2012-07-29       Impact factor: 27.401

8.  Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP‑ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells.

Authors:  Xiaoxing Feng; David W Koh
Journal:  Int J Oncol       Date:  2012-12-17       Impact factor: 5.650

Review 9.  Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.

Authors:  Julio Morales; Longshan Li; Farjana J Fattah; Ying Dong; Erik A Bey; Malina Patel; Jinming Gao; David A Boothman
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2014       Impact factor: 1.406
  9 in total

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