Alessandro Buda1, Maria Luisa Gasparri2, Andrea Puppo3, Liliana Mereu4, Elena De Ponti5, Giampaolo Di Martino6, Antonia Novelli3, Saverio Tateo4, Michael Muller2, Fabio Landoni6, Andrea Papadia2. 1. Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. Electronic address: ginoncmonza@gmail.com. 2. Department of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, Switzerland. 3. Department of Obstetrics and Gynecology, "Regina Montis Regalis" Hospital, Mondovì, Italy. 4. Department of Gynecology and Obstetrics, Santa Chiara Regional Hospital, Trento, Italy. 5. Department of Medical Physics, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. 6. Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Abstract
OBJECTIVE: The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND). METHODS: We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging. RESULTS: One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively. Pelvic LD was performed on 115 patients (67.2%) and aortic dissection was performed in 54/105 of the women in the S-LND group (51%). The 5-year comparison did not show a significant difference in the strategy adopted for nodal staging, regarding disease-free survival (DFS) [HR: 0.82; 95% CI 0.53-1.28; p = 0.390]. CONCLUSIONS: In this study focusing on women with EC in the HR groups, we did not find a difference in the 5-year DFS when comparing the SLN-A strategy with S-LND. The SLN strategy did not seem to compromise the prognosis of patients with a higher risk of recurrence.
OBJECTIVE: The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND). METHODS: We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging. RESULTS: One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively. Pelvic LD was performed on 115 patients (67.2%) and aortic dissection was performed in 54/105 of the women in the S-LND group (51%). The 5-year comparison did not show a significant difference in the strategy adopted for nodal staging, regarding disease-free survival (DFS) [HR: 0.82; 95% CI 0.53-1.28; p = 0.390]. CONCLUSIONS: In this study focusing on women with EC in the HR groups, we did not find a difference in the 5-year DFS when comparing the SLN-A strategy with S-LND. The SLN strategy did not seem to compromise the prognosis of patients with a higher risk of recurrence.
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Authors: William A Zammarrelli; Michelle Greenman; Eric Rios-Doria; Katie Miller; Vance Broach; Jennifer J Mueller; Emeline Aviki; Kaled M Alektiar; Robert A Soslow; Lora H Ellenson; Vicky Makker; Nadeem R Abu-Rustum; Mario M Leitao Journal: Gynecol Oncol Date: 2022-02-26 Impact factor: 5.304
Authors: A A Novelli; A Puppo; M Ceccaroni; E Olearo; G Monterossi; G Mantovani; S Pelligra; P L Olearo; F Fanfani; G Scambia Journal: Facts Views Vis Obgyn Date: 2020-10-08