Abhishek Vishnu1, Jina Choo2, Aya Kadota3, Emma J M Barinas-Mitchell4, Akira Fujiyoshi5, Dorothy Leann Long6, Takashi Hisamatsu7, Vasudha Ahuja4, Yasuyuki Nakamura8, Rhobert W Evans4, Katsuyuki Miura5, Kamal H Masaki9, Chol Shin10, Hirotsugu Ueshima5, Akira Sekikawa4. 1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Biostatistics, School of Public Health, West Virginia University, Morgantown, WV, United States. Electronic address: vishnu.abhishek.vishnu@mssm.edu. 2. College of Nursing, Korea University, Seoul, South Korea. 3. Department of School Nursing and Health Education, Osaka Kyoiku University, Kashiwara, Osaka, Japan. 4. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States. 5. Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan. 6. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States. 7. Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan; Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University, Izumo, Japan. 8. The First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. 9. Department of Geriatric Medicine, University of Hawaii, Honolulu, HI, United States. 10. Division of Pulmonary Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, South Korea.
Abstract
BACKGROUND: Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk. METHODS: We conducted a population-based study among apparently healthy middle-aged men aged 40-49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined. RESULTS: Whites (22.8%) had more than four-fold higher prevalence (p < 0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors - incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population. CONCLUSION: Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors.
BACKGROUND: Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk. METHODS: We conducted a population-based study among apparently healthy middle-aged men aged 40-49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined. RESULTS: Whites (22.8%) had more than four-fold higher prevalence (p < 0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors - incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population. CONCLUSION: Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors.
Authors: N Handa; M Matsumoto; H Maeda; H Hougaku; S Ogawa; R Fukunaga; S Yoneda; K Kimura; T Kamada Journal: Stroke Date: 1990-11 Impact factor: 7.914
Authors: Raymond D Miller; Michael S Phillips; Inho Jo; Miriam A Donaldson; Joel F Studebaker; Nicholas Addleman; Steven V Alfisi; Wendy M Ankener; Hamid A Bhatti; Chad E Callahan; Benjamin J Carey; Cheryl L Conley; Justin M Cyr; Vram Derohannessian; Rachel A Donaldson; Carolina Elosua; Stacey E Ford; Angela M Forman; Craig A Gelfand; Nicole M Grecco; Susan M Gutendorf; Cricket R Hock; Mark J Hozza; Soyoung Hur; Sun Mi In; Diana L Jackson; Sangmee Ahn Jo; Sung-Chul Jung; Sook Kim; Kuchan Kimm; Ellen F Kloss; Daniel C Koboldt; Jennifer M Kuebler; Feng-Shen Kuo; Jessica A Lathrop; Jong-Keuk Lee; Kathy L Leis; Stephanie A Livingston; Elizabeth G Lovins; Maria L Lundy; Sima Maggan; Matthew Minton; Michael A Mockler; David W Morris; Eric P Nachtman; Bermseok Oh; Chan Park; Chang-Wook Park; Nicholas Pavelka; Adrienne B Perkins; Stephanie L Restine; Ravi Sachidanandam; Andrew J Reinhart; Kathryn E Scott; Gira J Shah; Jatana M Tate; Shobha A Varde; Amy Walters; J Rebecca White; Yeon-Kyeong Yoo; Jong-Eun Lee; Michael T Boyce-Jacino; Pui-Yan Kwok Journal: Genomics Date: 2005-08 Impact factor: 5.736
Authors: Jonathan H Klein; Robert A Hegele; Daniel G Hackam; Marlys L Koschinsky; Murray W Huff; J David Spence Journal: Arterioscler Thromb Vasc Biol Date: 2008-07-03 Impact factor: 8.311