Literature DB >> 29887317

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.

Rebecca M Gibbs1, Scott Lipnick2, Joel W Bateman3, Lloyd Chen3, Henry C Cousins3, Elizabeth G Hubbard3, Geraldine Jowett1, Darren S LaPointe3, Maxine J McGredy3, Michelle N Odonkor3, Giuliana Repetti1, Elizabeth Thomas3, Lee L Rubin4.   

Abstract

The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Mesh：

Year:  2018        PMID： 29887317     DOI： 10.1016/j.stem.2018.05.019

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  12 in total

1.  Biologically Defined or Biologically Informed Traits Are More Heritable Than Clinically Defined Ones: The Case of Oral and Dental Phenotypes.

Authors:  Cary S Agler; Kevin Moss; Kamaira H Philips; Julie T Marchesan; Miguel Simancas-Pallares; James D Beck; Kimon Divaris
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

Review 2.  The Advent of Omics Sciences in Clinical Trials of Motor Neuron Diseases.

Authors:  Paola Ruffo; Sebastiano Cavallaro; Francesca Luisa Conforti
Journal:  J Pers Med       Date:  2022-05-07

Review 3.  Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities.

Authors:  Jenny Lange; Haiyan Zhou; Amy McTague
Journal:  Front Mol Neurosci       Date:  2022-06-27       Impact factor: 6.261

4.  Pharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons.

Authors:  Daniel Moakley; Joan Koh; Joao D Pereira; Daniel M DuBreuil; Anna-Claire Devlin; Eugene Berezovski; Kevin Zhu; Brian J Wainger
Journal:  Sci Rep       Date:  2019-07-25       Impact factor: 4.379

Review 5.  Neuroimaging-based pain biomarkers: definitions, clinical and research applications, and evaluation frameworks to achieve personalized pain medicine.

Authors:  Sean Mackey; Henry T Greely; Katherine T Martucci
Journal:  Pain Rep       Date:  2019-08-07

6.  Applying Deep Neural Network Analysis to High-Content Image-Based Assays.

Authors:  Samuel J Yang; Scott L Lipnick; Nina R Makhortova; Subhashini Venugopalan; Minjie Fan; Zan Armstrong; Thorsten M Schlaeger; Liyong Deng; Wendy K Chung; Liadan O'Callaghan; Anton Geraschenko; Dosh Whye; Marc Berndl; Jon Hazard; Brian Williams; Arunachalam Narayanaswamy; D Michael Ando; Philip Nelson; Lee L Rubin
Journal:  SLAS Discov       Date:  2019-07-08       Impact factor: 3.341

Review 7.  Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems.

Authors:  Florian J Raabe; Sabrina Galinski; Sergi Papiol; Peter G Falkai; Andrea Schmitt; Moritz J Rossner
Journal:  NPJ Schizophr       Date:  2018-11-19

Review 8.  Human in vitro models for understanding mechanisms of autism spectrum disorder.

Authors:  Aaron Gordon; Daniel H Geschwind
Journal:  Mol Autism       Date:  2020-04-16       Impact factor: 7.509

Review 9.  Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases.

Authors:  Lijun Chen; Jingjing Qu; Tianli Cheng; Xin Chen; Charlie Xiang
Journal:  Stem Cell Res Ther       Date:  2019-12-21       Impact factor: 6.832

Review 10.  Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders.

Authors:  Chuan-Jun Zhuo; Wei-Hong Hou; De-Guo Jiang; Hong-Jun Tian; Li-Na Wang; Feng Jia; Chun-Hua Zhou; Jing-Jing Zhu
Journal:  Neural Regen Res       Date:  2020-05       Impact factor: 5.135
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