Literature DB >> 29886546

Development of Mouse Monoclonal Antibodies Against Human Amyloid Fibril Proteins for Diagnostic and Research Purposes.

Gunilla T Westermark1, Elisabet Ihse2, Per Westermark3.   

Abstract

Commercial antibodies against varying proteins are often not optimal for identification of proteins in their amyloid fibril forms. Reasons can be the different conformation but also a variety of modifications like N- or C-terminal truncation. Therefore, development of own monoclonal antibodies against amyloid fibril proteins may be advantageous. This chapter gives suggestions of how to be successful in such approaches.

Entities:  

Keywords:  Amyloid; Degraded amyloid; Fibril; Hybridoma; Immunohistochemistry; Transthyretin; Western blot

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Substances：

Year:  2018        PMID： 29886546     DOI： 10.1007/978-1-4939-7816-8_24

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  5 in total

Review 1.  Congo Red and amyloids: history and relationship.

Authors:  Elmira I Yakupova; Liya G Bobyleva; Ivan M Vikhlyantsev; Alexander G Bobylev
Journal:  Biosci Rep       Date:  2019-01-15       Impact factor: 3.840

2.  Abdominal fat pad biopsies exhibit good diagnostic accuracy in patients with suspected transthyretin amyloidosis.

Authors:  Hedvig Paulsson Rokke; Nima Sadat Gousheh; Per Westermark; Ole B Suhr; Intissar Anan; Elisabet Ihse; Björn Pilebro; Jonas Wixner
Journal:  Orphanet J Rare Dis       Date:  2020-10-08       Impact factor: 4.123

3.  Amyloid fibril composition type is consistent over time in patients with Val30Met (p.Val50Met) transthyretin amyloidosis.

Authors:  Intissar Anan; Ole B Suhr; Katarzyna Liszewska; Jorge Mejia Baranda; Björn Pilebro; Jonas Wixner; Elisabet Ihse
Journal:  PLoS One       Date:  2022-03-31       Impact factor: 3.240

4.  Transthyretin amyloid deposits in lumbar spinal stenosis and assessment of signs of systemic amyloidosis.

Authors:  P Eldhagen; S Berg; L H Lund; P Sörensson; O B Suhr; P Westermark
Journal:  J Intern Med       Date:  2021-01-07       Impact factor: 8.989

5.  Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence.

Authors:  Diana Canetti; Paola Nocerino; Nigel B Rendell; Nicola Botcher; Janet A Gilbertson; Angel Blanco; Dorota Rowczenio; Alessandra Morelli; P Patrizia Mangione; Alessandra Corazza; Guglielmo Verona; Sofia Giorgetti; Loredana Marchese; Per Westermark; Philip N Hawkins; Julian D Gillmore; Vittorio Bellotti; Graham W Taylor
Journal:  J Pathol       Date:  2021-08-27       Impact factor: 9.883
  5 in total

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