| Literature DB >> 29886531 |
Urmi Sengupta1,2,3, Mariana Carretero-Murillo1,2,3, Rakez Kayed4,5,6.
Abstract
An increasing number of studies have demonstrated the existence of multiple conformational entities of tau, as have been observed for prion protein. We have developed and optimized techniques to isolate and study oligomeric tau strains both in vitro and ex vivo. Moreover, we have modified protocols that demonstrate the seeding properties of oligomeric tau strains that are capable of propagating in vivo. These methods and protocols are explained in this chapter.Entities:
Keywords: In vitro tau seeding; In vivo tau propagation; Tau oligomer isolation; Tau oligomeric strains
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Year: 2018 PMID： 29886531 DOI： 10.1007/978-1-4939-7816-8_9
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745