Adam P Mecca1,2,3, Hannah R Michalak1,2, Julia W McDonald1,2, Emily C Kemp1,2, Erika A Pugh1,2, Melinda L Becker1,2, Marcia C Mecca3,4, Christopher H van Dyck1,2,5,6. 1. Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA. 2. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. 3. Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA. 4. Geriatrics Section, Department of Internal Medicine, and Program on Aging, Yale University School of Medicine, New Haven, Connecticut, USA. 5. Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA. 6. Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Abstract
BACKGROUND: We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS: Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer's Disease Neuroimaging Initiative), a longitudinal cohort study. RESULTS: Sleep disturbance was not associated with decline in memory, executive function, or global cognition. The presence of sleep disturbance did not significantly increase the risk of diagnostic conversion in CN, early MCI, or late MCI participants. CONCLUSION: This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.
BACKGROUND: We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS: Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer's Disease Neuroimaging Initiative), a longitudinal cohort study. RESULTS:Sleep disturbance was not associated with decline in memory, executive function, or global cognition. The presence of sleep disturbance did not significantly increase the risk of diagnostic conversion in CN, early MCI, or late MCI participants. CONCLUSION: This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.
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