| Literature DB >> 29884864 |
Shamil Sh Afiyatullov1, Olesya I Zhuravleva2,3, Alexandr S Antonov2, Dmitrii V Berdyshev2, Mikhail V Pivkin2, Vladimir A Denisenko2, Roman S Popov2, Andrey V Gerasimenko4, Gunhild von Amsberg5, Sergey A Dyshlovoy2,3,5, Elena V Leshchenko2,3, Anton N Yurchenko2,3.
Abstract
Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM.Entities:
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Year: 2018 PMID： 29884864 DOI： 10.1038/s41429-018-0072-9
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649