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Literature DB >> 2988464

Prostaglandin (PG) E2 generation by cultured canine synovial fibroblasts exposed to microcrystals containing calcium.

Abstract

Immunoreactive prostaglandin (PG) E2 was released into the ambient medium in a dose dependent fashion when either hydroxyapatite (HA) or calcium pyrophosphate dihydrate (CPPD) crystals were added to canine synovial fibroblasts in tissue culture. PGE2 release peaked 6 to 9 hours after HA or CPPD crystals were added in the presence of serum but at 24 hours if they were added in the presence of lactalbumin hydrolysate. PGE2 release correlated with crystal endocytosis estimated qualitatively by serial phase contrast microscopy and time lapse photography. As postulated previously by others for monosodium urate crystals, prostaglandin production by synovial cells may also be related to the pathogenesis of the destructive arthropathies associated with HA or CPPD crystals.

Entities: Chemical Disease Species

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Year: 1985 PMID： 2988464 PMCID： PMC1001639 DOI： 10.1136/ard.44.5.316

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

17 in total

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Authors: H S Cheung; M T Story; D J McCarty
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Authors: D R Robinson; A H Tashjian; L Levine
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9. Phagocytosis of hydroxyapatite or calcium pyrophosphate dihydrate crystals by rabbit articular chondrocytes stimulates release of collagenase, neutral protease, and prostaglandins E2 and F2 alpha.

Authors: H S Cheung; P B Halverson; D J McCarty
Journal: Proc Soc Exp Biol Med Date: 1983-06

4. Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia.

Authors: H J Girschick; P Schneider; I Haubitz; O Hiort; H Collmann; M Beer; Y S Shin; H W Seyberth
Journal: Orphanet J Rare Dis Date: 2006-06-28 Impact factor: 4.123

4 in total