Daryl S Paulson1, Robert Topp2, Robert E Boykin3, Gregory Schultz4, Qingping Yang5. 1. BioScience Laboratories, Inc, Bozeman, MT. 2. Hahn School of Nursing and Health Sciences, University of San Diego, San Diego, CA. Electronic address: rtopp@sandiego.edu. 3. Sports Medicine and Shoulder Surgery Blue Ridge Bone and Joint/EmergeOrtho, Asheville, NC. 4. Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL. 5. Institute for Wound Research, University of Florida, Gainesville, FL.
Abstract
BACKGROUND: This study evaluated whether a multi-ingredient surfactant colloidal silver technology was noninferior to a 4% chlorhexidine gluconate (CHG) antiseptic on immediate and persistent antimicrobial activity. METHODS: The inguinal regions of 81 healthy adults were demarcated into 4 quadrants, and 3 were used for testing each product at baseline, 10 minutes, and 6 hours postapplication. The log of the number of colony forming units was obtained using a cylinder sampling technique. The 95% confidence interval of the test product to the control product with a margin of 0.65 was established as the upper limit of noninferiority. RESULTS: A total of 81 individuals were enrolled. The colloidal silver product was found to be noninferior to 4% CHG at both 10 minutes and 6 hours postapplication. CONCLUSIONS: The colloidal silver-based product was noninferior to the 4% CHG product at 10 minutes and 6 hours postapplication.
BACKGROUND: This study evaluated whether a multi-ingredient surfactant colloidal silver technology was noninferior to a 4% chlorhexidine gluconate (CHG) antiseptic on immediate and persistent antimicrobial activity. METHODS: The inguinal regions of 81 healthy adults were demarcated into 4 quadrants, and 3 were used for testing each product at baseline, 10 minutes, and 6 hours postapplication. The log of the number of colony forming units was obtained using a cylinder sampling technique. The 95% confidence interval of the test product to the control product with a margin of 0.65 was established as the upper limit of noninferiority. RESULTS: A total of 81 individuals were enrolled. The colloidal silver product was found to be noninferior to 4% CHG at both 10 minutes and 6 hours postapplication. CONCLUSIONS: The colloidal silver-based product was noninferior to the 4% CHG product at 10 minutes and 6 hours postapplication.
Authors: María I Quiñones-Vico; Ana Fernández-González; Elena Pérez-Castejón; Trinidad Montero-Vílchez; Salvador Arias-Santiago Journal: J Clin Med Date: 2021-02-08 Impact factor: 4.241