J Kraeima1, B Dorgelo2, H A Gulbitti3, R J H M Steenbakkers4, K P Schepman5, J L N Roodenburg6, F K L Spijkervet7, R H Schepers8, M J H Witjes9. 1. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: j.kraeima@umcg.nl. 2. Department of Radiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: b.dorgelo@umcg.nl. 3. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: h.a.gulbitti@umcg.nl. 4. Department of Radiation Oncology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: r.steenbakkers@umcg.nl. 5. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: k.p.schepman@umcg.nl. 6. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: j.l.n.roodenburg@umcg.nl. 7. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: f.k.l.spijkervet@umcg.nl. 8. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: r.h.schepers@umcg.nl. 9. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: m.j.h.witjes@umcg.nl.
Abstract
OBJECTIVES: 3D virtual surgical planning (VSP) and guided surgery has been proven to be an effective tool for resection and reconstruction of the mandible. Currently, most widely used 3D VSP approaches to mandibular resection do not include detailed tumour information in the VSP. This manuscript presents a strategy where the aim was to incorporate tumour visualisation into the 3D virtual plan. Three-dimensional VSP of the mandibular resections was based on the fusion of CT and MRI data which was subsequently applied in clinical practice. METHODS: All patients diagnosed with oral squamous cell carcinoma between 2014 and 2017 at the University Medical Centre Groningen were included. The tumour was delineated on the MRI data, after which this dataset was fused with the CT bone data in order to construct a 3D bone and tumour model for virtual resection planning. Guided resections were performed and post-operative evaluation quantified the accuracy of the resection. The histopathological findings and patient and tumour characteristics were compared to those of a historical cohort (2009-2014) of conventional mandibular continuity resections. RESULTS: Twenty-four patients were included in the cohort. The average deviation from planned resection was found to be 2.2 mm. Histopathologic analysis confirmed all resection planes (bone) were tumour free, compared to 96.4% in the historic cohort. CONCLUSION: MRI-CT base tumour visualisation and 3D resection planning is a safe and accurate method for oncologic resection of the mandible. It is an improvement on the current methods reported for 3D resection planning based solely on CT data.
OBJECTIVES: 3D virtual surgical planning (VSP) and guided surgery has been proven to be an effective tool for resection and reconstruction of the mandible. Currently, most widely used 3D VSP approaches to mandibular resection do not include detailed tumour information in the VSP. This manuscript presents a strategy where the aim was to incorporate tumour visualisation into the 3D virtual plan. Three-dimensional VSP of the mandibular resections was based on the fusion of CT and MRI data which was subsequently applied in clinical practice. METHODS: All patients diagnosed with oral squamous cell carcinoma between 2014 and 2017 at the University Medical Centre Groningen were included. The tumour was delineated on the MRI data, after which this dataset was fused with the CT bone data in order to construct a 3D bone and tumour model for virtual resection planning. Guided resections were performed and post-operative evaluation quantified the accuracy of the resection. The histopathological findings and patient and tumour characteristics were compared to those of a historical cohort (2009-2014) of conventional mandibular continuity resections. RESULTS: Twenty-four patients were included in the cohort. The average deviation from planned resection was found to be 2.2 mm. Histopathologic analysis confirmed all resection planes (bone) were tumour free, compared to 96.4% in the historic cohort. CONCLUSION: MRI-CT base tumour visualisation and 3D resection planning is a safe and accurate method for oncologic resection of the mandible. It is an improvement on the current methods reported for 3D resection planning based solely on CT data.
Authors: Nathalie Vosselman; Haye H Glas; Bram J Merema; Joep Kraeima; Harry Reintsema; Gerry M Raghoebar; Max J H Witjes; Sebastiaan A H J de Visscher Journal: J Pers Med Date: 2022-04-06
Authors: Elisa M Barroso; Yassine Aaboubout; Lisette C van der Sar; Hetty Mast; Aniel Sewnaik; Jose A Hardillo; Ivo Ten Hove; Maria R Nunes Soares; Lars Ottevanger; Tom C Bakker Schut; Gerwin J Puppels; Senada Koljenović Journal: Front Oncol Date: 2021-03-30 Impact factor: 6.244
Authors: Bingjiang Qiu; Jiapan Guo; Joep Kraeima; Haye Hendrik Glas; Weichuan Zhang; Ronald J H Borra; Max Johannes Hendrikus Witjes; Peter M A van Ooijen Journal: J Pers Med Date: 2021-05-31