Mohammad-Javad Ahmadizadeh1, Mehdi Rezaei2. 1. Behavioral Science Research Center, Life Style Institute, Baqiyatallah University of Medical Science, Tehran, Iran. 2. Department of Psychology, Lorestan University, Khoramabad, Iran. Electronic address: Rezaee.mehdi15@yahoo.com.
Abstract
BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is a potential non-invasive treatment for post-traumatic stress disorder (PTSD). However, the treatment parameters of rTMS required to optimize therapeutic efficacy remains unclear. OBJECTIVE: The aim of the present study was to investigate the efficacy of bilateral rTMS and unilateral right rTMS and compare the efficacy of bilateral rTMS and unilateral rTMS on PTSD symptoms. METHODS:Sixty-five veterans with current combat-related PTSD symptoms were randomly selected to receive bilateral rTMS (1200 pulses at 20 Hz followed by 1200 pulses per session), unilateral right rTMS (2400 pulses at 20 Hz) or sham rTMS over the dorsolateral prefrontal cortex (DLPFC). RESULTS: Results showed significant differences among the 3 groups. Patients demonstrated significant PTSD symptom reductions in the bilateral group compared to the sham group in session five and endpoint. There were no significant differences between the bilateral and unilateral right groups at endpoint. Unilateral right group when compared to sham group showed greater symptom reductions from baseline to endpoint. There were no significant differences between the unilateral right and sham groups in session five. CONCLUSION: Our findings suggest that bilateral and unilateral right rTMS are superior to sham rTMS but does not support the hypothesis that bilateral rTMS is more effective than unilateral high-frequency right-sided rTMS.
RCT Entities:
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is a potential non-invasive treatment for post-traumatic stress disorder (PTSD). However, the treatment parameters of rTMS required to optimize therapeutic efficacy remains unclear. OBJECTIVE: The aim of the present study was to investigate the efficacy of bilateral rTMS and unilateral right rTMS and compare the efficacy of bilateral rTMS and unilateral rTMS on PTSD symptoms. METHODS: Sixty-five veterans with current combat-related PTSD symptoms were randomly selected to receive bilateral rTMS (1200 pulses at 20 Hz followed by 1200 pulses per session), unilateral right rTMS (2400 pulses at 20 Hz) or sham rTMS over the dorsolateral prefrontal cortex (DLPFC). RESULTS: Results showed significant differences among the 3 groups. Patients demonstrated significant PTSD symptom reductions in the bilateral group compared to the sham group in session five and endpoint. There were no significant differences between the bilateral and unilateral right groups at endpoint. Unilateral right group when compared to sham group showed greater symptom reductions from baseline to endpoint. There were no significant differences between the unilateral right and sham groups in session five. CONCLUSION: Our findings suggest that bilateral and unilateral right rTMS are superior to sham rTMS but does not support the hypothesis that bilateral rTMS is more effective than unilateral high-frequency right-sided rTMS.
Authors: Michelle R Madore; F Andrew Kozel; Leanne M Williams; L Chauncey Green; Mark S George; Paul E Holtzheimer; Jerome A Yesavage; Noah S Philip Journal: J Affect Disord Date: 2021-10-20 Impact factor: 4.839
Authors: Gay Florian; Allison Singier; Bruno Aouizerate; Francesco Salvo; Thomas C M Bienvenu Journal: Front Psychiatry Date: 2022-07-01 Impact factor: 5.435
Authors: Amber N Edinoff; Tanner L Hegefeld; Murray Petersen; James C Patterson; Christopher Yossi; Jacob Slizewski; Ashley Osumi; Elyse M Cornett; Adam Kaye; Jessica S Kaye; Vijayakumar Javalkar; Omar Viswanath; Ivan Urits; Alan D Kaye Journal: Front Psychiatry Date: 2022-05-31 Impact factor: 5.435
Authors: Alexander McGirr; Daniel J Devoe; Amelie Raedler; Chantel T Debert; Zahinoor Ismail; Marcelo T Berlim Journal: Can J Psychiatry Date: 2020-12-23 Impact factor: 4.356
Authors: Abrahão Fontes Baptista; Adriana Baltar; Alexandre Hideki Okano; Alexandre Moreira; Ana Carolina Pinheiro Campos; Ana Mércia Fernandes; André Russowsky Brunoni; Bashar W Badran; Clarice Tanaka; Daniel Ciampi de Andrade; Daniel Gomes da Silva Machado; Edgard Morya; Eduardo Trujillo; Jaiti K Swami; Joan A Camprodon; Katia Monte-Silva; Katia Nunes Sá; Isadora Nunes; Juliana Barbosa Goulardins; Marom Bikson; Pedro Sudbrack-Oliveira; Priscila de Carvalho; Rafael Jardim Duarte-Moreira; Rosana Lima Pagano; Samuel Katsuyuki Shinjo; Yossi Zana Journal: Front Neurol Date: 2020-11-25 Impact factor: 4.003