Literature DB >> 29882583

Phase I dose-escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia.

Oliver G Ottmann1, Carsten Müller-Tidow2, Alwin Krämer3, Richard F Schlenk4, Michael Lübbert5, Gesine Bug1, Utz Krug2, Tilmann Bochtler3, Florian Voss6, Tillmann Taube7, Dan Liu7, Pilar Garin-Chesa8, Hartmut Döhner4.   

Abstract

Entities:  

Keywords:  acute myeloid leukaemia (AML); new drug development; new drugs for leukaemia; oncology; pharmacokinetics

Mesh：

Substances：

Year:  2018        PMID： 29882583     DOI： 10.1111/bjh.15204

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


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  11 in total

Review 1.  Emerging agents and regimens for treatment of relapsed and refractory acute myeloid leukemia.

Authors:  Longzhen Cui; Yan Liu; Yifan Pang; Tingting Qian; Liang Quan; Zhiheng Cheng; Yifeng Dai; Xu Ye; Ying Pang; Jinlong Shi; Xiaoyan Ke; Depei Wu; Lin Fu
Journal:  Cancer Gene Ther       Date:  2019-07-11       Impact factor: 5.987

Review 2.  The role of aurora A and polo-like kinases in high-risk lymphomas.

Authors:  Carlos Murga-Zamalloa; Kedar V Inamdar; Ryan A Wilcox
Journal:  Blood Adv       Date:  2019-06-11

3.  Volasertib as a monotherapy or in combination with azacitidine in patients with myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia: summary of three phase I studies.

Authors:  Uwe Platzbecker; Joerg Chromik; Jan Krönke; Hiroshi Handa; Stephen Strickland; Yasushi Miyazaki; Martin Wermke; Wataru Sakamoto; Yoshifumi Tachibana; Tillmann Taube; Ulrich Germing
Journal:  BMC Cancer       Date:  2022-05-21       Impact factor: 4.638

Review 4.  Novel Targeted Therapeutics in Acute Myeloid Leukemia: an Embarrassment of Riches.

Authors:  Nicole R Grieselhuber; Alice S Mims
Journal:  Curr Hematol Malig Rep       Date:  2021-03-18       Impact factor: 3.952

5.  RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.

Authors:  Ryan M Carr; Denis Vorobyev; Terra Lasho; David L Marks; Ezequiel J Tolosa; Alexis Vedder; Luciana L Almada; Andrey Yurcheko; Ismael Padioleau; Bonnie Alver; Giacomo Coltro; Moritz Binder; Stephanie L Safgren; Isaac Horn; Xiaona You; Eric Solary; Maria E Balasis; Kurt Berger; James Hiebert; Thomas Witzig; Ajinkya Buradkar; Temeida Graf; Peter Valent; Abhishek A Mangaonkar; Keith D Robertson; Matthew T Howard; Scott H Kaufmann; Christopher Pin; Martin E Fernandez-Zapico; Klaus Geissler; Nathalie Droin; Eric Padron; Jing Zhang; Sergey Nikolaev; Mrinal M Patnaik
Journal:  Nat Commun       Date:  2021-05-18       Impact factor: 14.919

Review 6.  The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?

Authors:  Andrea Ghelli Luserna di Rorà; Giovanni Martinelli; Giorgia Simonetti
Journal:  J Hematol Oncol       Date:  2019-11-26       Impact factor: 17.388

7.  The landscape of gene co-expression modules correlating with prognostic genetic abnormalities in AML.

Authors:  Chao Guo; Ya-Yue Gao; Qian-Qian Ju; Chun-Xia Zhang; Ming Gong; Zhen-Ling Li
Journal:  J Transl Med       Date:  2021-05-29       Impact factor: 5.531

Review 8.  CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes.

Authors:  Aileen Roth; Adrian Gihring; Joachim Bischof; Leiling Pan; Franz Oswald; Uwe Knippschild
Journal:  Cancers (Basel)       Date:  2022-03-05       Impact factor: 6.639

9.  Adjunctive Volasertib in Patients With Acute Myeloid Leukemia not Eligible for Standard Induction Therapy: A Randomized, Phase 3 Trial.

Authors:  Hartmut Döhner; Argiris Symeonidis; Dries Deeren; Judit Demeter; Miguel A Sanz; Achilles Anagnostopoulos; Jordi Esteve; Walter Fiedler; Kimmo Porkka; Hee-Je Kim; Je-Hwan Lee; Kensuke Usuki; Stefano D'Ardia; Chul Won Jung; Olga Salamero; Heinz-August Horst; Christian Recher; Philippe Rousselot; Irwindeep Sandhu; Koen Theunissen; Felicitas Thol; Konstanze Döhner; Veronica Teleanu; Daniel J DeAngelo; Tomoki Naoe; Mikkael A Sekeres; Valerie Belsack; Miaomiao Ge; Tillmann Taube; Oliver G Ottmann
Journal:  Hemasphere       Date:  2021-08-02

Review 10.  Mitotic Poisons in Research and Medicine.

Authors:  Jan Škubník; Michal Jurášek; Tomáš Ruml; Silvie Rimpelová
Journal:  Molecules       Date:  2020-10-12       Impact factor: 4.411
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