Karn Wijarnpreecha1, Panadeekarn Panjawatanan2, Omar Y Mousa3, Wisit Cheungpasitporn4, Surakit Pungpapong3, Patompong Ungprasert5. 1. 1Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA. 2. 2Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. 3. Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, FL, USA. 4. 4Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, MS, USA. 5. 5Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Abstract
BACKGROUND/ OBJECTIVES: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. METHODS: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Seven case-control studies with 2,307,393 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC among current smokers and former smokers was significantly lower than nonsmokers with the pooled odds ratio of 0.31 (95% CI, 0.18-0.53) and 0.52 (95% CI, 0.44-0.61), respectively. The risk remained significantly lower among current smokers and former smokers compared with nonsmokers even when only patients with PSC without inflammatory bowel disease were included. CONCLUSIONS: A significantly decreased risk of PSC among current and former smokers was demonstrated in this study.
BACKGROUND/ OBJECTIVES: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. METHODS: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: Seven case-control studies with 2,307,393 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC among current smokers and former smokers was significantly lower than nonsmokers with the pooled odds ratio of 0.31 (95% CI, 0.18-0.53) and 0.52 (95% CI, 0.44-0.61), respectively. The risk remained significantly lower among current smokers and former smokers compared with nonsmokers even when only patients with PSC without inflammatory bowel disease were included. CONCLUSIONS: A significantly decreased risk of PSC among current and former smokers was demonstrated in this study.
Authors: J E Eaton; B D Juran; E J Atkinson; E M Schlicht; X Xie; M de Andrade; C S Lammert; V A Luketic; J A Odin; A A Koteish; K V Kowdley; K B Chopra; G M Hirschfield; N P Chalasani; K N Lazaridis Journal: Aliment Pharmacol Ther Date: 2015-03-17 Impact factor: 8.171
Authors: Natalie A Molodecky; Hashim Kareemi; Rohan Parab; Herman W Barkema; Hude Quan; Robert P Myers; Gilaad G Kaplan Journal: Hepatology Date: 2011-05 Impact factor: 17.425
Authors: Kiran Bambha; W Ray Kim; Jayant Talwalkar; Heidi Torgerson; Joanne T Benson; Terry M Therneau; Edward V Loftus; Barbara P Yawn; E Rolland Dickson; L Joseph Melton Journal: Gastroenterology Date: 2003-11 Impact factor: 22.682
Authors: Raúl Herzog; María José Álvarez-Pasquin; Camino Díaz; José Luis Del Barrio; José Manuel Estrada; Ángel Gil Journal: BMC Public Health Date: 2013-02-19 Impact factor: 3.295
Authors: Ming-Hsi Wang; Omar Y Mousa; Jessica J Friton; Laura E Raffals; Jonathan A Leighton; Shabana F Pasha; Michael F Picco; Kelly C Cushing; Kelly Monroe; Billy D Nix; Rodney D Newberry; William A Faubion Journal: Inflamm Bowel Dis Date: 2020-04-11 Impact factor: 5.325
Authors: M D Voskuil; L M Spekhorst; K W J van der Sloot; B H Jansen; G Dijkstra; C J van der Woude; F Hoentjen; M J Pierik; A E van der Meulen; N K H de Boer; M Löwenberg; B Oldenburg; E A M Festen; R K Weersma Journal: J Crohns Colitis Date: 2021-06-22 Impact factor: 9.071