Literature DB >> 2988138

Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma.

H Koprowski, M Herlyn, G Balaban, A Parmiter, A Ross, P Nowell.   

Abstract

Epidermal growth factor (EGF) receptor is expressed selectively by human melanoma cells which show the presence of an extra copy of chromosome 7. None of the cells of benign pigmented lesions (nevi) or radial growth phase (nonmetastatic) primary melanoma expressed EGF receptor and none of these cells showed an extra copy of chromosome 7. The results indicate that a single extra dose of a gene (for EGF receptor) may provide a selective advantage to cells in the late stages of tumorigenesis.

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Year:  1985        PMID： 2988138     DOI： 10.1007/bf01534687

Source DB:  PubMed          Journal:  Somat Cell Mol Genet        ISSN： 0740-7750


  28 in total

Review 1.  Melanoma: from mutations to medicine.

Authors:  Hensin Tsao; Lynda Chin; Levi A Garraway; David E Fisher
Journal:  Genes Dev       Date:  2012-06-01       Impact factor: 11.361

Review 2.  Monoclonal antibodies to epidermal growth factor receptors in studies of receptor structure and function.

Authors:  T Kawamoto; G H Sato; K Takahashi; M Nishi; S Taniguchi; J D Sato
Journal:  Cytotechnology       Date:  1990-05       Impact factor: 2.058

3.  Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines.

Authors:  A J Linnenbach; K Huebner; E P Reddy; M Herlyn; A H Parmiter; P C Nowell; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

Review 4.  Growth factors and oncogenes as targets in melanoma: lost in translation?

Authors:  Lawrence Kwong; Lynda Chin; Stephan N Wagner
Journal:  Adv Dermatol       Date:  2007

5.  Met amplification and tumor progression in Cdkn2a-deficient melanocytes.

Authors:  Matthew W Vanbrocklin; James P Robinson; Todd Whitwam; Adam R Guilbeault; Julie Koeman; Pamela J Swiatek; George F Vande Woude; Joseph D Khoury; Sheri L Holmen
Journal:  Pigment Cell Melanoma Res       Date:  2009-04-29       Impact factor: 4.693

Review 6.  Genetic markers on chromosome 7.

Authors:  L C Tsui
Journal:  J Med Genet       Date:  1988-05       Impact factor: 6.318

7.  Polysomy of chromosome 7 is correlated with overexpression of the erbB oncogene in human glioblastoma cell lines.

Authors:  W Henn; N Blin; K D Zang
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

8.  Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

Authors:  J J Smith; R Derynck; M Korc
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

Review 9.  Modulation of tumor cell gene expression and phenotype by the organ-specific metastatic environment.

Authors:  R Radinsky
Journal:  Cancer Metastasis Rev       Date:  1995-12       Impact factor: 9.264

10.  Characterization of a continuous human glioma cell line DBTRG-05MG: growth kinetics, karyotype, receptor expression, and tumor suppressor gene analyses.

Authors:  C A Kruse; D H Mitchell; B K Kleinschmidt-DeMasters; W A Franklin; H G Morse; E B Spector; K O Lillehei
Journal:  In Vitro Cell Dev Biol       Date:  1992 Sep-Oct
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