Literature DB >> 2988127

Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia.

M Krönke, W J Leonard, J M Depper, W C Greene.   

Abstract

Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.

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Year:  1985        PMID： 2988127     DOI： 10.1126/science.2988127

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein.

Authors:  H Albrecht; A N Shakhov; C V Jongeneel
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

Review 2.  Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

Authors:  M R Smith; W C Greene
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808

3.  Molecular cloning and structure of the human interleukin 2 receptor gene.

Authors:  N Ishida; H Kanamori; T Noma; T Nikaido; H Sabe; N Suzuki; A Shimizu; T Honjo
Journal:  Nucleic Acids Res       Date:  1985-11-11       Impact factor: 16.971

4.  Regulation of interleukin 2 receptors on T cells from multiple sclerosis patients.

Authors:  E C DeFreitas; M Sandberg-Wollheim; K Schonely; M Boufal; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

Review 5.  T-cell control by human T-cell leukemia/lymphoma virus type 1.

Authors:  Genoveffa Franchini; Risaku Fukumoto; Jake R Fullen
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.490

6.  Chromosomal localization of HTLV-1 viral integration sites using in situ hybridization: detection of a novel IL2R fragment.

Authors:  M J Macera; P Szabo; R S Verma
Journal:  Mol Gen Genet       Date:  1992-09

7.  Morphological and immunological changes of hairy cell leukemia during alpha-2-interferon therapy.

Authors:  M A Fridrik; G Wahl; W Herbinger; W Schützenberger; G Gastl; C Huber; M Krönke; I Höpfel
Journal:  Blut       Date:  1989-05

8.  Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.

Authors:  J R Gnarra; H Otani; M G Wang; O W McBride; M Sharon; W J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

9.  Altered expression of protein kinase C, lck, and CD45 in a 12-O-tetradecanoylphorbol-13-acetate-dependent leukemic T-cell variant that expresses a high level of interleukin-2 receptor.

Authors:  K M Tchou-Wong; I B Weinstein
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

10.  Interleukin 1 gene expression in adult T cell leukemia.

Authors:  Y Wano; T Hattori; M Matsuoka; K Takatsuki; A O Chua; U Gubler; W C Greene
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808
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