Masahiko Kemmochi1, Shigeru Sasaki2,3, Masako Takahashi4, Tomitaka Nishimura4, Chisa Aizawa4, Jun Kikuchi5. 1. Kemmochi Orthopedic Surgery Sports Clinic, KOSSMOS Medical Corporation, 42-1 Higashi honcho, Ota, Gunma, 373-0026, Japan. 2. Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan. 3. Japan Community Health Care Organization, Yamanashi Hospital, Kofu, Yamanashi, Japan. 4. Kemmochi Orthopedic Surgery Sports Clinic Nurse Part, KOSSMOS Medical Corporation, Ota, Gunma, Japan. 5. Kemmochi Orthopedic Surgery Sports Clinic Rehabilitation Part, KOSSMOS Medical Corporation, Ota, Gunma, Japan.
Abstract
INTRODUCTION: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. MATERIALS AND METHODS: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint. Another five patients as a control group underwent meniscal repair without PRF and PRP (non-PRF group). The groups were compared in terms of clinical results (Tegner Activity Level Scale, Lysholm Knee Scoring Scale, and International Knee Documentation Committee [IKDC] scores) and changes in magnetic resonance imaging (MRI) findings before surgery and 6 months after surgery. RESULTS: The Lysholm and IKDC scores improved in all patients postoperatively. However, there was no significant differencies in the postoperative score between the PRF group and the non-PRF group. Follow-up MRI findings did not clearly show improvements. CONCLUSIONS: PRF and PRP are autologous, safe, and cost-effective sources of growth factors. Therefore, we propose a new application of PRF and PRP for autologous transplantation in meniscus repair surgery.
INTRODUCTION: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. MATERIALS AND METHODS: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint. Another five patients as a control group underwent meniscal repair without PRF and PRP (non-PRF group). The groups were compared in terms of clinical results (Tegner Activity Level Scale, Lysholm Knee Scoring Scale, and International Knee Documentation Committee [IKDC] scores) and changes in magnetic resonance imaging (MRI) findings before surgery and 6 months after surgery. RESULTS: The Lysholm and IKDC scores improved in all patients postoperatively. However, there was no significant differencies in the postoperative score between the PRF group and the non-PRF group. Follow-up MRI findings did not clearly show improvements. CONCLUSIONS: PRF and PRP are autologous, safe, and cost-effective sources of growth factors. Therefore, we propose a new application of PRF and PRP for autologous transplantation in meniscus repair surgery.
Entities:
Keywords:
Arthroscopy; Meniscal repair; Platelet-rich fibrin; Platelet-rich plasma; Regenerative medicine
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