OBJECTIVE: Metacognition, or the ability to accurately identify, appraise, and monitor one's deficits, is commonly impaired in Alzheimer's disease (AD). Poor metacognition prevents correct appraisal of a range of physical, cognitive, and emotional symptoms and facilitates anosognosia, which has important clinical implications for individuals (e.g., diminished treatment adherence, increased engagement in high-risk situations) and caregivers (e.g., higher burden). However, the neural correlates of metacognitive disturbance are still debated in the literature, partly because of the subjective nature of traditional awareness measures. METHOD: An objective Feeling of Knowing (FOK) task was used to measure metamemory capacity in a group of cognitively diverse older adults, including 14 with mild to moderate AD and 20 cognitively healthy older adults. The association between three different objective metamemory measures of the FOK task and regional cortical thickness (12 bilateral regions of interest [ROIs] hypothesized to support self-awareness) was analyzed using partial correlations. RESULTS: Less accurate metamemory at the local and global levels was associated with reduced right posterior cingulate cortical thickness, r = -0.42, p = .02 and reduced right medial prefrontal, r = -0.39, p = .029, respectively. CONCLUSIONS: To our knowledge, this was the first study to examine metacognition in relation to cortical thickness. Both global and local metamemory functions appear to rely on the integrity of right sided midline regions, known to be important for processing self-referential information. Findings are conceptualized with regard to the Default Mode Network, and also considered in relation to recent findings pointing to the right insula as a region critical for self-awareness. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
OBJECTIVE: Metacognition, or the ability to accurately identify, appraise, and monitor one's deficits, is commonly impaired in Alzheimer's disease (AD). Poor metacognition prevents correct appraisal of a range of physical, cognitive, and emotional symptoms and facilitates anosognosia, which has important clinical implications for individuals (e.g., diminished treatment adherence, increased engagement in high-risk situations) and caregivers (e.g., higher burden). However, the neural correlates of metacognitive disturbance are still debated in the literature, partly because of the subjective nature of traditional awareness measures. METHOD: An objective Feeling of Knowing (FOK) task was used to measure metamemory capacity in a group of cognitively diverse older adults, including 14 with mild to moderate AD and 20 cognitively healthy older adults. The association between three different objective metamemory measures of the FOK task and regional cortical thickness (12 bilateral regions of interest [ROIs] hypothesized to support self-awareness) was analyzed using partial correlations. RESULTS: Less accurate metamemory at the local and global levels was associated with reduced right posterior cingulate cortical thickness, r = -0.42, p = .02 and reduced right medial prefrontal, r = -0.39, p = .029, respectively. CONCLUSIONS: To our knowledge, this was the first study to examine metacognition in relation to cortical thickness. Both global and local metamemory functions appear to rely on the integrity of right sided midline regions, known to be important for processing self-referential information. Findings are conceptualized with regard to the Default Mode Network, and also considered in relation to recent findings pointing to the right insula as a region critical for self-awareness. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Authors: Federico d'Oleire Uquillas; Heidi I L Jacobs; Aaron P Schultz; Bernard J Hanseeuw; Rachel F Buckley; Jorge Sepulcre; Alvaro Pascual-Leone; Nancy J Donovan; Keith A Johnson; Reisa A Sperling; Patrizia Vannini Journal: Cereb Cortex Date: 2020-03-14 Impact factor: 5.357
Authors: William D Hopkins; Mary C Mareno; Sarah J Neal Webb; Steven J Schapiro; Mary A Raghanti; Chet C Sherwood Journal: Am J Primatol Date: 2020-11-10 Impact factor: 2.371
Authors: Carlos Muñoz-Neira; Andrea Tedde; Elizabeth Coulthard; N Jade Thai; Catherine Pennington Journal: Neuroimage Clin Date: 2019-11-05 Impact factor: 4.881
Authors: Patrizia Vannini; Federico d'Oleire Uquillas; Heidi I L Jacobs; Jorge Sepulcre; Jennifer Gatchel; Rebecca E Amariglio; Bernard Hanseeuw; Kathryn V Papp; Trey Hedden; Dorene M Rentz; Alvaro Pascual-Leone; Keith A Johnson; Reisa A Sperling Journal: Neuroimage Clin Date: 2019-11-18 Impact factor: 4.881