Ina Zaimi1, Cloë L Sparreboom1, Hester F Lingsma2, Pascal G Doornebosch3, Anand G Menon1,4, Gert-Jan Kleinrensink5, Johannes Jeekel5, Michel W J M Wouters6,7, Johan F Lange1,4. 1. Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands. 2. Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands. 3. Department of Surgery, IJsselland Ziekenhuis, Capelle aan den IJssel, The Netherlands. 4. Department of Surgery, Havenziekenhuis, Rotterdam, The Netherlands. 5. Department of Neuroscience-Anatomy, Erasmus University Medical Center, Rotterdam, The Netherlands. 6. Dutch Institute for Clinical Auditing, Leiden, The Netherlands. 7. Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Abstract
BACKGROUND: The aim of this study was to investigate the effect of age on CAL and its associated mortality. METHODS: Data were derived from the Dutch ColoRectal Audit. All patients undergoing resection for colorectal cancer in the Netherlands between January 2011 and December 2016 were included. Univariable and multivariable logistic regressions were performed to test the effect of age on CAL and its associated mortality. RESULTS: In total, 45 488 patients were included. The incidence of CAL was 6.4% in patients <60 years old, 5.5% in patients 60-69 years old, 5.4% in patients 70-80 years old, and 4.9% in patients ≥80 years old (P < 0.001). Multivariate analysis showed that age was protective for CAL (OR 0.965 per 5 years, 95% CI 0.941-0.985, P < 0.001). Mortality after CAL was 1.3% in patients <60 years old, 4.8% in patients 60-69 years old, 12.3% in patients 70-80 years old, and 27.0% in patients >80 years old (P < 0.001). Older age was associated with mortality following CAL (OR 1.497 per 5 years 95% CI 1.364-1.647, P < 0.001). CONCLUSIONS: This population-based study suggests a protective effect of increased age on CAL after colorectal cancer resection. However, older age is strongly associated with mortality after CAL.
BACKGROUND: The aim of this study was to investigate the effect of age on CAL and its associated mortality. METHODS: Data were derived from the Dutch ColoRectal Audit. All patients undergoing resection for colorectal cancer in the Netherlands between January 2011 and December 2016 were included. Univariable and multivariable logistic regressions were performed to test the effect of age on CAL and its associated mortality. RESULTS: In total, 45 488 patients were included. The incidence of CAL was 6.4% in patients <60 years old, 5.5% in patients 60-69 years old, 5.4% in patients 70-80 years old, and 4.9% in patients ≥80 years old (P < 0.001). Multivariate analysis showed that age was protective for CAL (OR 0.965 per 5 years, 95% CI 0.941-0.985, P < 0.001). Mortality after CAL was 1.3% in patients <60 years old, 4.8% in patients 60-69 years old, 12.3% in patients 70-80 years old, and 27.0% in patients >80 years old (P < 0.001). Older age was associated with mortality following CAL (OR 1.497 per 5 years 95% CI 1.364-1.647, P < 0.001). CONCLUSIONS: This population-based study suggests a protective effect of increased age on CAL after colorectal cancer resection. However, older age is strongly associated with mortality after CAL.
Authors: Nicholas P McKenna; Katherine A Bews; Robert R Cima; Cynthia S Crowson; Elizabeth B Habermann Journal: J Gastrointest Surg Date: 2019-06-26 Impact factor: 3.452
Authors: Kai S Lehmann; Carsten Klinger; Johannes Diers; Heinz-Johannes Buhr; Christoph-Thomas Germer; Armin Wiegering Journal: BJS Open Date: 2021-11-09